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A systematic review on thyroid organoid models: time-trend and its achievements

机译：甲状腺有机体模型的系统综述：时间趋势及其成就

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Current in vitro models have played important roles in improving knowledge and understanding of cellular and molecular biology, but cannot exactly recapitulate the physiology of human tissues such as thyroid. In this article, we conducted a systematic review to present scientific and methodological time-trends of the reconstruction and generation of 3D functional thyroid follicles and organoids for thyroid research in health and disease. Web of Science (ISI), Scopus, Embase, Cochrane Library, and PubMed were systematically searched for papers published since 1950 to May 2020 in English language, using the predefined keywords. 212 articles were reviewed and finally 28 papers that met the inclusion and exclusion criteria were selected. Among the evidence for the examination of 3D cell culture methods in thyroid research, there were only a few studies related to the organoid technology and its potential applications in understanding morphological, histological, and physiological characteristics of the thyroid gland and reconstructing this tissue. Besides, there was no study using organoids to investigate the tumorigenesis process of thyroid. Based on the results of this study, despite all the limitations and controversies, the exciting and promising organoid technology offers researchers a wide range of potential applications for more accurate modeling of thyroid in health and diseases and provides an excellent preclinical in vitro platform. In future, organoid technology can provide a better understanding of the molecular mechanisms of pathogenesis and tumorigenesis of thyroid tissue and more effective treatment for related disorders due to more accurate simulation of the thyroid physiology.
机译：目前的体外模型在提高细胞和分子生物学的知识和理解方面发挥了重要作用，但不能准确地重现人体组织（如甲状腺）的生理学。在这篇文章中，我们进行了一次系统的回顾，以展示三维功能性甲状腺滤泡和类器官重建和生成的科学和方法学时间趋势，用于甲状腺健康和疾病研究。科学网（ISI）、Scopus、Embase、科克伦图书馆和PubMed使用预定义的关键字系统地搜索1950年至2020年5月以英语发表的论文。对212篇文章进行了综述，最终选择了28篇符合纳入和排除标准的论文。在甲状腺研究中检查3D细胞培养方法的证据中，只有少数研究与类器官技术及其在理解甲状腺的形态学、组织学和生理学特征以及重建该组织方面的潜在应用有关。此外，还没有使用类器官研究甲状腺的肿瘤发生过程。基于这项研究的结果，尽管存在各种限制和争议，但这项令人兴奋且有前途的类有机物技术为研究人员提供了更精确的甲状腺健康和疾病建模的广泛潜在应用，并提供了一个极好的临床前体外平台。在未来，类器官技术可以更好地理解甲状腺组织的发病机制和肿瘤发生的分子机制，并通过更准确地模拟甲状腺生理学来更有效地治疗相关疾病。

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