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首页> 外文期刊>American Journal of Physiology >FSPE Applied Bioenergetics Lab, University of Novi Sad, Novi Sad, Serbia and Faculty of Health Sciences, University of Pecs, Pecs, Hungary
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FSPE Applied Bioenergetics Lab, University of Novi Sad, Novi Sad, Serbia and Faculty of Health Sciences, University of Pecs, Pecs, Hungary

机译：FSPE应用生物植物实验室，诺维萨，塞尔维亚，塞尔维亚，佩奇大学，匈牙利，匈牙利大学

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A traditional dogma of creatine metabolism claims a spatial separation between the production and utilization of endogenous creatine (1), the main high-energy phosphate-storage molecule in mammals. Creatine (2-[carbamimidoyl(methyl) aminojacetic acid) is formed by the methylation of guanidi-noacetic acid, a reaction catalyzed by guanidinoacetate N-methyltransferase (GAMT) expressed mainly in the liver, kidney, pancreas, and testis. Creatine is then released into the circulation and taken up predominantly by the skeletal muscle, the main organ of creatine deposition and usage. The Human Protein Atlas catalogs absent expression of GAMT protein in the muscle tissues [https://www. proteinatlas.org/ENSG00000130005-GAMT], suggesting no creatine biosynthesis inside the myocytes. However, both earlier and contemporary studies document otherwise, with the myocardium and skeletal muscle appear to have their own machinery for creatine synthesis, which perhaps calls for adjusting an old Daradism.
机译：传统的肌酸代谢教条主张内源性肌酸（1）的生产和利用之间存在空间分离，内源性肌酸是哺乳动物体内主要的高能磷酸盐储存分子。肌酸（2-[氨基甲酰（甲基）氨基乙酸）是由胍乙酸的甲基化形成的，胍乙酸是由胍乙酸N-甲基转移酶（GAMT）催化的反应主要表达于肝脏、肾脏、胰腺和睾丸。然后肌酸被释放到循环中，主要由骨骼肌吸收，骨骼肌是肌酸沉积和使用的主要器官。人类蛋白质图谱记录了GAMT蛋白在肌肉组织中的缺失表达[https://www.proteinatlas。org/ENSG0000130005-GAMT]，表明心肌细胞内没有肌酸生物合成。然而，早期和当代的研究都证明，心肌和骨骼肌似乎有自己的肌酸合成机制，这可能需要调整旧的达拉第学说。

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