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首页> 外文期刊>Annual Review of Analytical Chemistry >Structure Determination of Natural Products by Mass Spectrometry
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Structure Determination of Natural Products by Mass Spectrometry

机译：质谱测定天然产物的结构

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I review laboratory research on the development of mass spectrometric methodology for the determination of the structure of natural products of biological and medical interest, which I conducted from 1958 to the end of the twentieth century. The methodology was developed by converting small peptides to their corresponding polyamino alcohols to make them amenable to mass spectrometry, thereby making it applicable to whole proteins. The structures of alkaloids were determined by analyzing the fragmentation of a known alkaloid and then using the results to deduce the structures of related compounds. Heparin-like structures were investigated by determining their molecular weights from the mass of protonated molecular ions of complexes with highly basic, synthetic peptides. Mass spectrometry was also employed in the analysis of lunar material returned by the Apollo missions. A miniaturized gas chromatograph mass spectrometer was sent to Mars on board of the two Viking 1976 spacecrafts.
机译：我回顾了从1958年到20世纪末进行的有关质谱分析方法开发的实验室研究，该方法用于确定具有生物学和医学意义的天然产物的结构。通过将小肽转化为相应的聚氨基醇以使其适合质谱分析，从而使其适用于完整蛋白质，从而开发了该方法。生物碱的结构是通过分析已知生物碱的碎片来确定的，然后利用结果推论出相关化合物的结构。通过从具有高度碱性的合成肽的复合物的质子化分子离子的质量中确定分子量，来研究类肝素结构。质谱法还用于分析阿波罗任务返回的月球物质。微型气相色谱质谱仪被送往两架维京1976航天器上的火星。

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