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首页> 外文期刊>Annual Review of Analytical Chemistry >Advances in Mass Spectrometric Tools for Probing Neuropeptides
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Advances in Mass Spectrometric Tools for Probing Neuropeptides

机译：探测神经肽的质谱工具的进展

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摘要

Neuropeptides are important mediators in the functionality of the brain and other neurological organs. Because neuropeptides exist in a wide range of concentrations, appropriate characterization methods are needed to provide dynamic, chemical, and spatial information. Mass spectrometry and compatible tools have been a popular choice in analyzing neuropeptides. There have been several advances and challenges, both of which are the focus of this review. Discussions range from sample collection to bioinformatic tools, although avenues such as quantitation and imaging are included. Further development of the presented methods for neuropeptidomic mass spectrometric analysis is inevitable, which will lead to a further understanding of the complex interplay of neuropeptides and other signaling molecules in the nervous system.
机译：神经肽是大脑和其他神经器官功能的重要介体。由于神经肽的浓度范围很广，因此需要适当的表征方法来提供动态，化学和空间信息。质谱分析法和兼容工具已成为分析神经肽的流行选择。有一些进步和挑战，这都是本次审查的重点。尽管包括定量和成像等方法，但讨论范围从样本收集到生物信息学工具。所提出的用于神经肽质谱分析的方法的进一步发展是不可避免的，这将导致对神经肽和神经系统中其他信号分子之间复杂相互作用的进一步理解。

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