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首页> 外文期刊>Climacteric: the journal of the International Menopause Society >To be or not to be in sexual desire: the androgen dilemma
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To be or not to be in sexual desire: the androgen dilemma

机译：处于或不处于性欲中：雄激素困境

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The androgen milieu and sexual desire in women seem to be tightly linked because they both decline with age. However, we are still missing a cut-off plasma level for androgens (total testosterone, free testosterone) or androgen precursors (androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)) to diagnose androgen deficiency in clinical practice. Apart from the complex multidimensional nature of sexual desire across the reproductive lifespan, the correlation between measurements of testosterone and specific signs and symptoms has been difficult because, according to guidelines, most available assays are unreliable at baseline and under hormonal treatments. Recent data obtained with accurate methods based on mass spectrometry to measure total testosterone levels found a significant positive association with sexual desire, arousal and masturbation in midlife US women across the menopausal transition. Even in a European cohort of healthy women aged 19-65 years, sexual desire, measured with a validated questionnaire, correlated overall with free testosterone and androstenedione measured with mass spectrometry. Collectively, these data support the therapeutic use of testosterone for low desire and sexual dysfunction in those clinical conditions in which androgen deficiency may be accurately diagnosed.
机译：女性的雄激素环境和性欲似乎紧密相关，因为它们都随着年龄的增长而下降。然而，在临床实践中，我们仍然缺少雄激素（总睾丸激素，游离睾丸激素）或雄激素前体（雄烯二酮，脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS））的临界血浆水平，以诊断雄激素缺乏症。除了在整个生殖寿命中性欲的复杂多维性质之外，睾丸激素的测量值与特定体征和症状之间的相关性也很困难，因为根据指南，大多数可用的测定在基线和激素治疗下均不可靠。使用基于质谱法测量总睾丸激素水平的准确方法获得的最新数据发现，在绝经过渡期的美国中年妇女中，性欲，唤醒和手淫呈显着正相关。即使在欧洲年龄在19-65岁之间的健康女性队列中，通过经过验证的问卷调查得出的性欲，也总体上与通过质谱法测量的游离睾丸激素和雄烯二酮相关。总体而言，这些数据支持睾丸激素在那些可以准确诊断出雄激素缺乏症的临床情况下用于低欲和性功能障碍的治疗用途。

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