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首页> 外文期刊>Behavioural Brain Research: An International Journal >The multivariate concentric square field test reveals different behavioural profiles in male AA and ANA rats with regard to risk taking and environmental reactivity.
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The multivariate concentric square field test reveals different behavioural profiles in male AA and ANA rats with regard to risk taking and environmental reactivity.

机译：多元同心方场检验揭示了男性AA和ANA大鼠在冒险和环境反应性方面的不同行为特征。

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摘要

The aim of the present investigation was to compare the behavioural profiles in alcohol-preferring AA (Alko, alcohol) and alcohol-avoiding ANA (Alko, non-alcohol) rats. Twelve adult, alcohol-naive male AA and ANA rats were tested in the recently established multivariate concentric square field (MCSF) test. The more traditional open field and elevated plus-maze tests were used as reference tests. Six weeks after the initial MCSF test, a repeated testing was used to explore differences in acquired recognition after a previous experience. The results revealed distinct differences between the two lines. The ANA rats were generally more active in the three tests. In the MCSF, parameters of risk taking and shelter seeking indicated differences between the two lines. The ANA rats had higher shelter seeking behaviour and less risk taking behaviour than the AA rats. Repeated exposure to the MCSF caused a general decrease in activity and reduction in the number of visits to the various zones, especially evident in the ANA rats. The ANA rats showed more shelter seeking than the AA rats and also more shelter seeking than in the first trial, supporting an "anxiety-like" profile in these rats. In conclusion, the parameters related to risk taking and shelter seeking revealed obvious differences between AA and ANA rats. The higher risk taking behaviour seen in the AA rats might relate to their innate propensity for high voluntary alcohol intake. The results are discussed in relation to the reported neurobiological differences and in relation to other alcohol-preferring and alcohol-avoiding rat lines.
机译：本研究的目的是比较在偏好酒精的AA（酒精，无酒精）和无酒精ANA（酒精，无酒精）大鼠中的行为特征。在最近建立的多变量同心方场（MCSF）测试中测试了十二只成年，无酒精的雄性AA和ANA大鼠。比较传统的开放式测试和高架迷宫测试被用作参考测试。初次MCSF测试六周后，根据先前的经验，使用重复测试来探索获得的识别的差异。结果显示两条线之间存在明显差异。在这三个测试中，ANA大鼠通常更为活跃。在MCSF中，冒险和寻求庇护的参数表明了两条线之间的差异。 ANA大鼠比AA大鼠具有更高的寻求庇护行为和较少的冒险行为。反复接触MCSF会导致活动普遍下降，并且减少对各个区域的探访次数，这在ANA大鼠中尤为明显。 ANA大鼠比AA大鼠表现出更多的寻求庇护的地方，并且比第一次试验中表现出更高的寻求庇护的地方，这支持了这些大鼠的“焦虑样”特征。总之，与冒险和寻求庇护所相关的参数表明，AA和ANA大鼠之间存在明显差异。在AA大鼠中发现较高的冒险行为可能与它们对高自愿性饮酒的天生倾向有关。讨论的结果与所报告的神经生物学差异以及与其他偏爱酒精和偏爱酒精的大鼠系有关。

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