• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotechnology >Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications
【24h】

Edible mushroom (Flammulina velutipes) as biosource for silver nanoparticles: from synthesis to diverse biomedical and environmental applications

机译：食用蘑菇（Flammulina Velutipes）作为银纳米粒子的生物源：从合成到不同的生物医学和环境应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using Flammulina velutipes as biosource. In the study, a simple aqueous extract of F. velutipes was utilized to reduce the AgNO3 into stable elemental silver (Ag-0) at a nanometric scale. The NPs had average size of 21.4 nm, spherical morphology, and were highly stable and pure. The characterized nanoparticles were exploited for a broad range of biomedical applications including bacteriocidal, fungicidal, leishmanicidal, in vitro antialzheimer's, antioxidant, anti-diabetic and biocompatibility studies. Our findings showed that F. velutipes mediated AgNPs exhibited high activity against MDR bacterial strains and spore forming fungal strains. All the tested urinary tract infection bacterial isolates, were resistant to non-coated antibiotics but by applying 1% of the synthesized AgNPs, the bactericidal potential of the tested antibiotics enhanced manifolds. The NPs also exhibited dose-dependent cytotoxic potential against Leishmania tropica with significant LC50 of 248 mu g ml(-1) for promastigote and 251 mu g ml(-1) for amastigote forms of the parasite. Furthermore, promising antialzheimer and antidiabetic activities were observed as significant inhibition of alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE) and butrylcholineterase (BChE) were noted. Moreover, remarkable biocompatible nature of the particles was found against human red blood cells. The biosynthesized AgNPs as photocatalyst, also resulted in 98.2% degradation of indigo carmine dye within 140 min. Owing to ecofriendly synthesis, biosafe nature and excellent physicochemical properties F. velutipes AgNPs can be exploited as novel candidates for multifaceted biomedical and environmental applications.
机译：目前的研究报告了以金针菇为生物源，用于多种生物医学和环境应用的先进、生态友好和生物合成的银纳米颗粒。在这项研究中，一种简单的水提取物被用来在纳米尺度上将AgNO3还原为稳定的元素银（Ag-0）。纳米粒的平均粒径为21.4nm，呈球形，具有高度的稳定性和纯度。所表征的纳米颗粒被用于广泛的生物医学应用，包括杀菌、杀菌、利什曼原虫、体外抗阿尔茨海默病、抗氧化剂、抗糖尿病和生物相容性研究。我们的研究结果表明，F.velutipes介导的AgNPs对MDR菌株和孢子形成真菌菌株表现出高活性。所有受试尿路感染细菌分离株均对未包被的抗生素耐药，但通过应用1%的合成AgNP，受试抗生素的杀菌潜力增强。纳米粒对热带利什曼原虫也表现出剂量依赖性的细胞毒性潜力，前鞭毛体的显著LC50为248μg ml（-1），无鞭毛体形式的显著LC50为251μg ml（-1）。此外，由于α-淀粉酶、α-葡萄糖苷酶、乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的显著抑制，观察到有希望的抗阿尔茨海默病和抗糖尿病活性。此外，还发现这些颗粒对人体红细胞具有显著的生物相容性。生物合成的AgNPs作为光催化剂，也在140分钟内降解了98.2%的靛蓝胭脂红染料。由于生态友好的合成，F.velutipes AgNPs的生物安全性和优异的物理化学性质可被开发为多方面生物医学和环境应用的新候选者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号