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首页> 外文期刊>New Journal of Chemistry >Holistic quality evaluation of compound liquorice tablets using capillary electrophoresis fingerprinting combined with chemometric methods
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Holistic quality evaluation of compound liquorice tablets using capillary electrophoresis fingerprinting combined with chemometric methods

机译：使用毛细管电泳的化合物液体片剂的整体质量评价毛细管电泳与化学计量方法相结合

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摘要

With the popularity of herbal medicines (HMs) throughout the world, their quality is becoming a key issue. Because of the complicated phytochemical matrices and characteristic synergistic effect caused by the presence of multi-components, the quality control of HMs is facing great challenges. Compound liquorice tablets (CLQTs) have a long history as a Chinese herbal formula to treat cough and expectoration. In this paper, an eco-friendly capillary zone electrophoresis (CZE) fingerprinting method was developed for the separation and detection of 36 batches of CLQTs from nine manufacturers. The fingerprint information index, FI, was calculated for choosing satisfactory test conditions. Quantitative comparison of seven major components showed no significant difference between the samples, illustrating its poor discrimination ability for CLQTs. Furthermore, in combination with chemometrics (principal component analysis and hierarchical clustering analysis), the samples were preliminarily clustered into three groups and exhibited a good qualitative consistency in the same manufacturer. Subsequently, a novel equal weight ratio quantitative fingerprinting method was introduced and proved to be a comprehensive and effective method for further discrimination and holistic quality evaluation of the 36 samples. The samples were divided into five quality grades (grades 1-5) based on the ratio qualitative similarity (S-r), ratio quantitative similarity (P-r) and fingerprint-leveling coefficient (alpha). The approach proposed in this study will be a valuable counterpart for the holistic quality control of HMs or herbal preparations.
机译：随着草药（HMs）在世界各地的普及，其质量正成为一个关键问题。由于其复杂的植物化学基质和多组分的协同效应，HMs的质量控制面临巨大挑战。复方甘草片（CLQTs）作为一种治疗咳嗽和咳痰的中草药配方由来已久。本文建立了一种环境友好的毛细管区带电泳（CZE）指纹图谱方法，用于分离和检测来自9家制造商的36批CLQT。计算指纹信息指数FI，以选择满意的试验条件。七个主要成分的定量比较显示，样本之间没有显著差异，说明其对CLQT的识别能力较差。此外，结合化学计量学（主成分分析和层次聚类分析），样本初步聚类为三组，并在同一制造商中表现出良好的质量一致性。随后，提出了一种新的等重比定量指纹图谱方法，并证明该方法是一种全面有效的方法，可用于36个样本的进一步鉴别和整体质量评价。根据比率定性相似性（S-r）、比率定量相似性（P-r）和指纹水平系数（alpha），将样品分为五个质量等级（1-5级）。本研究中提出的方法将为HMs或草药制剂的整体质量控制提供有价值的对应方法。

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  • 来源
    《New Journal of Chemistry》 |2021年第5期|共10页
  • 作者

    Gong Dandan; Zheng Zijia; Chen Jinyu; Pang Ying; Sun Guoxiang;

  • 作者单位

    Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Liaoning Peoples R China;

    Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Liaoning Peoples R China;

    Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Liaoning Peoples R China;

    Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Liaoning Peoples R China;

    Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Liaoning Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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