The influence of PM(2.5 )exposure on non-alcoholic fatty liver disease

Chen Jiaxin; Wu Lei; Yang Guang; Zhang Cong; Liu Xiaofang; Sun Xiance; Chen Xin; Wang Ningning

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The influence of PM(2.5 )exposure on non-alcoholic fatty liver disease

机译：PM（2.5）暴露对非酒精性脂肪肝病的影响

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摘要

Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter < 2.5 mu m, PM2.5) and the incidence of non-alcoholic fatty liver disease (NAFLD). By referring to previous studies on the pathogenesis of NAFLD and PM2.5 exposure-induced metabolic damage, we summarized the possible mediating pathways through which PM2.5 exposure can cause the phenotype and progression of NAFLD. Crucially, PM2.5 exposure is considered to have an impact on the classic hypothesis "multiple hits" of NAFLD. In addition, we also concluded that exposure to PM2.5 can promote the development of NAFLD by destroying the intestinal epithelium and microbiotic homeostasis, triggering endoplasmic reticulum stress, inducing abnormal expression of specific microRNA or inflammatory factors.

机译：新的研究表明，暴露于环境细颗粒物（空气动力学直径<2.5μm，PM2.5）与非酒精性脂肪肝（NAFLD）的发病率之间存在显著关系。参考以往关于NAFLD和PM2发病机制的研究。5暴露诱导的代谢损伤，我们总结了PM2可能通过的介导途径。5暴露可导致NAFLD的表型和进展。关键是PM2。5暴露被认为对NAFLD的经典假设“多次撞击”有影响。此外，我们还得出结论，暴露于PM2。5可通过破坏肠上皮和微生物稳态，触发内质网应激，诱导特异性microRNA或炎症因子的异常表达，促进NAFLD的发展。

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来源
《Life sciences》 |2021年第1期|共5页
作者
Chen Jiaxin; Wu Lei; Yang Guang; Zhang Cong; Liu Xiaofang; Sun Xiance; Chen Xin; Wang Ningning;
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作者单位

Dalian Med Univ Sch Publ Hlth Dalian Liaoning Peoples R China;

Dalian Med Univ Sch Publ Hlth Dalian Liaoning Peoples R China;

Dalian Med Univ Sch Publ Hlth Dept Food Nutr &

Safety Dalian Liaoning Peoples R China;

Dalian Med Univ Sch Publ Hlth Dept Food Nutr &

Safety Dalian Liaoning Peoples R China;

Dalian Med Univ Sch Publ Hlth Dept Food Nutr &

Safety Dalian Liaoning Peoples R China;

Dalian Med Univ Global Hlth Res Ctr Occupat &

Environm Hlth Dept Dalian Peoples R China;

Dalian Med Univ Sch Publ Hlth Dept Epidemiol Dalian Liaoning Peoples R China;

Dalian Med Univ Sch Publ Hlth Dept Food Nutr &

Safety Dalian Liaoning Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Non-alcoholic fatty liver disease (NAFLD); Fine particulate matter (PM2.5); Pathogenesis;

机译：非酒精性脂肪肝;细颗粒物（PM2.5）;发病机制;

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专利

1. Prenatal exposure to diesel exhaust PM_(2.5) programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet [J] . Wang Xiaoke, Yang Yuxue, Zhu Piaoyu, Environmental Pollution . 2019,第PTa1期

机译：产前暴露于柴油机排气PM_（2.5）的非酒精性脂肪肝病在成年男性后代的小鼠喂养正常味噌和高脂饮食中
2. Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease [J] . Linqiang Zhang, Shasha Liao, Zhiguo Zhang, Biology Open . 2016,第10期

机译：树sh（Tupaia belangeri chinensis），一种非酒精性脂肪性肝病的新型非肥胖动物模型树sh（Tupaia belangeri chinensis），一种非酒精性脂肪性肝病的新型非肥胖动物模型。树sh（Tupaia belangeri chinensis）），一种非酒精性脂肪肝疾病的新型非肥胖动物模型
3. Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease [J] . Linqiang Zhang, Shasha Liao, Zhiguo Zhang, Biology Open . 2016,第10期

机译：树sh（Tupaia belangeri chinensis），一种非酒精性脂肪性肝病的新型非肥胖动物模型树sh（Tupaia belangeri chinensis），一种非酒精性脂肪性肝病的新型非肥胖动物模型。树sh（Tupaia belangeri chinensis）），一种非酒精性脂肪肝疾病的新型非肥胖动物模型
4. The influence of hepatic steatosis on the evaluation of fibrosis with non-alcoholic fatty liver disease by acoustic radiation force impulse [C] . Yanrong Guo, Haoming Lin, Xinyu Zhang, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

机译：肝硬化对辐射力冲击对非酒精性脂肪肝病纤维化评价的影响
5. An Investigation into the Influence of Dietary Saturated Fat and Quercetin Supplementation on Adiposity, Macrophage Behavior, Inflammation, and Non-Alcoholic Fatty-Liver Disease. [D] . Enos, Reilly T. 2013

机译：膳食中饱和脂肪和槲皮素的补充对肥胖，巨噬细胞行为，炎症和非酒精性脂肪肝疾病的影响的调查。
6. Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways [O] . Tunyu Jian, Xiaoqin Ding, Yuexian Wu, 2018

机译：通过调节IRs-1 / Akt和CYP2E1 / JNK途径Lo叶类黄酮对PM2.5诱导的非酒精性脂肪肝的肝保护作用。
7. Hepatoprotective Effect of Loquat Leaf Flavonoids in PM2.5-Induced Non-Alcoholic Fatty Liver Disease via Regulation of IRs-1/Akt and CYP2E1/JNK Pathways [O] . Tunyu Jian, Xiaoqin Ding, Yuexian Wu, 2018

机译：枇杷叶类黄酮在PM2.5诱导的非酒精性脂肪肝病中的肝保护作用通过调节IRS-1 / AKT和CYP2E1 / JNK途径
8. Guidance for the Network Design and Optimum Site Exposure for PM2.5 and PM10 [R] . Watson, J. G., Chow, J. C., DuBois, D., 1997

机译：pm2.5和pm10的网络设计和最佳站点暴露指南

The influence of PM(2.5 )exposure on non-alcoholic fatty liver disease

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