MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha

Bhavya Bharathan; Easwer H. V; Vilanilam G. C.; Anand C. R.; Sreelakshmi K.; Urulangodi Madhusoodanan; Rajalakshmi P.; Neena Issac; Padmakrishnan C. J.; Menon Girish R.; Krishnakumar K.; Deepti A. N.; Gopala Srinivas

首页> 外文期刊>Life sciences >MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha

【24h】

MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha

机译：Mutt Homolog1在胶质瘤中具有多方面的作用，并且是缺氧诱导因子1α的表观策划

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Aims: The study focused on the expression and role of a recent potential cancer therapeutic target protein, MutT Homolog1 (MTH1). MTH1 gets activated in an increased reactive oxygen species (ROS) environment and removes the oxidized nucleotides from the cell. The study aimed to check the role of MTH1 in DNA damage and apoptosis, migration and angiogenesis and also to examine its regulation in glioma.

机译：目的：这项研究集中于最近潜在的癌症治疗靶蛋白MutT同源物1（MTH1）的表达和作用。MTH1在活性氧（ROS）增加的环境中被激活，并从细胞中去除氧化的核苷酸。本研究旨在检测MTH1在DNA损伤、凋亡、迁移和血管生成中的作用，并检测其在胶质瘤中的调节作用。

著录项

来源
《Life sciences》 |2021年第1期|共17页
作者
Bhavya Bharathan; Easwer H. V; Vilanilam G. C.; Anand C. R.; Sreelakshmi K.; Urulangodi Madhusoodanan; Rajalakshmi P.; Neena Issac; Padmakrishnan C. J.; Menon Girish R.; Krishnakumar K.; Deepti A. N.; Gopala Srinivas;
展开▼
作者单位

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Biochem Hosp Wing Thiruvananthapuram 695011;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Neurosurg Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Neurosurg Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Biochem Hosp Wing Thiruvananthapuram 695011;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Biochem Hosp Wing Thiruvananthapuram 695011;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Biochem Hosp Wing Thiruvananthapuram 695011;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Pathol Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Pathol Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Biochem Hosp Wing Thiruvananthapuram 695011;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Neurosurg Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Neurosurg Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Pathol Thiruvananthapuram 695011 Kerala India;

Sree Chitra Tirunal Inst Med Sci &

Technol Dept Biochem Hosp Wing Thiruvananthapuram 695011;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
MTH1; Hif1 alpha; Glioma; Survival; Migration; DNA damage;

机译：MTH1;Hif1α;胶质瘤;生存迁移DNA损伤;

相似文献

外文文献
中文文献
专利

1. Hypoxia-inducible factor-1 alpha regulates the role of vascular endothelial growth factor on pulmonary arteries of rats with hypoxia-induced pulmonary hypertension [J] . 李启芳, 戴爱国中华医学杂志（英文版） . 2004,第007期
2. Influence of hypoxia-inducible factor 1-alpha on neuronal apoptosis in a rat model of hypoxia- or hypoxia-ischemia-induced brain injury [J] . Lihua Li, Yi Qu, Li Zhang, 中国神经再生研究（英文版） . 2009,第012期
3. Influence of hypoxia-inducible factor 1-alpha on neuronal apoptosis in a rat model of hypoxia- or hypoxia-ischemia-induced brain injury [J] . Lihua Li, Yi Qu, Li Zhang, 中国神经再生研究：英文版 . 2009,第012期
4. Hypoxia Inducible Factor-1 Alpha Correlates the Expression ofHeme Oxygenase 1 Gene in Pulmonary Arteries of Ratwith Hypoxia-induced Pulmonary Hypertension [J] . Qi-FangLI, Ai-GuoDAI 生物化学与生物物理学报：英文版 . 2004,第002期
5. MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha (vol 29, 118673, 2020) [J] . Bhavya Bharathan, Easwer H. V., Vilanilam G. C., Life sciences . 2021,第1期

机译：Mutt Homolog1在胶质瘤中具有多方面的作用，并且是缺氧诱导因子1α的表观策划（Vol 29,118673,2020）
6. Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats [J] . Shi Xudan, Doycheva Desislava Met, Xu Liang, Neurobiology of disease . 2016,第Null期

机译：缺氧诱导因子1α诱导的Sestrin2通过抑制新生鼠严重缺氧缺血性损伤后的VEGF保护血脑屏障
7. Single nucleotide polymorphisms and serologic levels of hypoxia-inducible factor1 alpha and vascular endothelial growth factor are associated with increased risk of oral submucous fibrosis in gutka users among a North Indian population [J] . Gupta Shalini R., Sharma Alpana, Gupta Nidhi, Oral surgery, oral medicine, oral pathology oral radiology . 2020,第5期

机译：单核苷酸多态性和缺氧诱导因子1α和血管内皮生长因子的血管内皮生长因子与北印度人口中古贺用户中的口腔粘膜纤维化的风险增加有关
8. Hypoxia-inducible factor-1/spl alpha/ (HIF-1/spl alpha/) and photodynamic therapy [C] . Lin-Hung Wei, Chia-Hung Chou, Jen-Liang Su Asian and Pacific Rim Symposium on Biophotonics . 2004

机译：缺氧诱导因子-1 /SPLα/（HIF-1 /SPLα/）和光动力治疗
9. Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos. [D] . Mohamed, Amira F. 2007

机译：低氧诱导因子-1α（HIF-1alpha）及其在斑马鱼（Danio rerio）胚胎的低氧预处理和基因表达模式中的作用。
10. CBIO-41MutT HOMOLOG1 EXPRESSION IS UP-REGULATED IN MALIGNANT GLIOMA [O] . Marco Timmer, Sara Kannampuzha, Roland Goldbrunner 2015

机译：CBIO-41MutT HOMOLOG1表达在恶性胶质瘤中上调
11. Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats [O] . Xudan Shi, Desislava Met Doycheva, Liang Xu, 2016

机译：缺氧诱导因子1α诱导的Sestrin2通过抑制新生大鼠的严重缺氧缺血性损伤后通过抑制VEGF来保护血脑屏障
12. Hypoxia Inducible Factor 1 (HIF-1) Activation in U87 Glioma Cells Involves a Decrease in Reactive Oxygen Species Production and Protein Kinase C Activity [R] . Forbes, R. A. 1998

机译：U87神经胶质瘤细胞中的缺氧诱导因子1（HIF-1）活化涉及活性氧生成和蛋白激酶C活性的降低

MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha

摘要

著录项

相似文献

相关主题

期刊订阅