3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model

Yu Honglin; Zhu Jingbo; Chang Lingyu; Liang Chaozhao; Li Xiaohu; Wang Wei

首页> 外文期刊>Life sciences >3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model

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3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model

机译：通过抑制单侧输尿管阻塞小鼠模型中的需氧糖溶解，3-溴吡合物减少肾纤维化和成纤维细胞活化

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AIMs: Enhanced aerobic glycolysis is a motivation of fibroblast-myofibroblast transdifferentiation (FMT), leading to kidney fibrosis. 3-Bromopyruvate (3-BrPA) is a glycolysis inhibitor and has fibrosis-protected effect in liver. This study aims to explore the effects of 3-BrPA on aerobic glycolysis and kidney fibrosis in a unilateral ureteral obstruction (UUO) mice model and transforming growth factor-beta 1(TGF-beta 1)-stimulated normal rat kidney fibroblast (NRK-49F) cell model in vitro.

机译：目的：增强的有氧糖酵解是成纤维细胞-肌成纤维细胞转分化（FMT）的动机，导致肾纤维化。3-溴丙酮酸（3-BrPA）是一种糖酵解抑制剂，对肝脏具有纤维化保护作用。本研究旨在探讨3-BrPA对单侧输尿管梗阻（UUO）小鼠模型和转化生长因子β1（TGFβ1）刺激的正常大鼠肾成纤维细胞（NRK-49F）模型体外有氧糖酵解和肾纤维化的影响。

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来源
《Life sciences》 |2021年第1期|共9页
作者
Yu Honglin; Zhu Jingbo; Chang Lingyu; Liang Chaozhao; Li Xiaohu; Wang Wei;
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作者单位

Anhui Med Univ Dept Radiol Affiliated Hosp 1 218 Ji Xi Rd Hefei 230022 Anhui Peoples R China;

Anhui Med Univ Clin Coll 1 Hefei 230032 Anhui Peoples R China;

Anhui Med Univ Clin Coll 1 Hefei 230032 Anhui Peoples R China;

Anhui Med Univ Inst Urol Dept Urol Affiliated Hosp 1 218 Ji Xi Rd Hefei 230022 Anhui Peoples;

Anhui Med Univ Dept Radiol Affiliated Hosp 1 218 Ji Xi Rd Hefei 230022 Anhui Peoples R China;

Anhui Med Univ Inst Urol Dept Urol Affiliated Hosp 1 218 Ji Xi Rd Hefei 230022 Anhui Peoples;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Kidney fibrosis; 3-Bromopyruvate; Aerobic glycolysis; Myofibroblast;

机译：肾纤维化;3-溴丙酮酸;有氧糖酵解;肌成纤维细胞;

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1. 3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation [J] . Jie Liu, Wang Wang, Lei Wang, 中华医学杂志（英文版） . 2020,第001期
2. VEGF ameliorates tubulointerstitial fibrosis in unilateral ureteral obstruction mice via inhibition of epithelial-mesenchymal transition [J] . Yao-guo LIAN, Qiu-gen ZHOU, Ying-juan ZHANG, 中国药理学报：英文版 . 2011,第012期
3. Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis [J] . Bing-mu XIN, Xiao-xing WANG, Wen JIN, 中国药理学报：英文版 . 2010,第012期
4. Angiotensin receptor blockade decreases fibrosis and fibroblast expression in a rat model of unilateral ureteral obstruction. [J] . Kellner D, Chen J, Richardson I, The Journal of Urology . 2006,第2期

机译：在单侧输尿管阻塞的大鼠模型中，血管紧张素受体阻滞降低了纤维化和成纤维细胞的表达。
5. Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts [J] . Yang Shen, Naijun Miao, Jinlan Xu, International Journal of Molecular Sciences . 2016,第2期

机译：二甲双胍可预防单侧输尿管梗阻小鼠的肾纤维化，并抑制Ang II诱导的肾成纤维细胞产生ECM。
6. Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice [J] . Human gene therapy . 2020,第5a6期

机译：外源miR-29a在单侧输尿管阻塞小鼠中衰减肌肉萎缩和肾纤维化
7. Vitamin D Reduces Myofibroblast Formation and Collagen 1 Expression Through Upregulating eNOS Expression in Kidney Fibrosis Model in Mice [C] . Nur Arfian, Santosa Budiharjo, Sagita Mega Sekar Kencana, International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering . 2018

机译：维生素D通过上调小鼠肾脏纤维化模型中eNOS的表达减少成肌纤维细胞的形成和1型胶原的表达。
8. In Vitro Evaluations of Hexokinase-2 Inhibition with 3-Bromopyruvate Encapsulated in Targeted Liposomal Formulations using 3D Spheroid Models of Tumor Aerobic Glycolysis [D] . Gandham, Srujan Kumar. 2014

机译：用肿瘤有氧糖醇的3D球状模型包封3-溴吡合他分用3-溴吡合他分包封的六酮酶-2抑制的体外评价
9. Effects of exendin-4 on the intrarenal renin-angiotensin system and interstitial fibrosis in unilateral ureteral obstruction mice: Exendin-4 and unilateral ureteral obstruction [O] . Ying Le, Zongji Zheng, Junyu Xue, 2016

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10. PEGylated pUR4/FUD peptide inhibitor of fibronectin fibrillogenesis decreases fibrosis in murine Unilateral Ureteral Obstruction model of kidney disease [O] . Bianca R. Tomasini-Johansson, Pawel W. Zbyszynski, Inger Toraason, 2018

机译：纤连蛋白原纤维生成的聚乙二醇化的PUR4 / FUD肽抑制剂降低了肾病的小鼠单侧输尿管梗阻模型的纤维化

3-Bromopyruvate decreased kidney fibrosis and fibroblast activation by suppressing aerobic glycolysis in unilateral ureteral obstruction mice model

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