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Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection

机译：用于生物标志物检测的磁共振成像造影剂的研究进展

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Recent advances in magnetic resonance imaging (MRI) contrast agents have provided new capabilities for biomarker detection through molecular imaging. MRI contrast agents based on the T-2 exchange mechanism have more recently expanded the armamentarium of agents for molecular imaging. Compared with T-1 and T-2* agents, T-2 exchange agents have a slower chemical exchange rate, which improves the ability to design these MRI contrast agents with greater specificity for detecting the intended biomarker. MRI contrast agents that are detected through chemical exchange saturation transfer (CEST) have even slower chemical exchange rates. Another emerging class of MRI contrast agents uses hyperpolarized C-13 to detect the agent with outstanding sensitivity. These hyperpolarized C-13 agents can be used to track metabolism and monitor characteristics of the tissue microenvironment. Together, these various MRI contrast agents provide excellent opportunities to develop molecular imaging for biomarker detection.
机译：磁共振成像（MRI）造影剂的最新进展为通过分子成像检测生物标志物提供了新功能。最近，基于T-2交换机制的MRI造影剂扩展了分子成像剂的装备库。与T-1和T-2 *试剂相比，T-2交换剂的化学交换速度较慢，从而提高了设计这些MRI造影剂的能力，从而可以更特异性地检测预期的生物标志物。通过化学交换饱和转移（CEST）检测到的MRI造影剂的化学交换速率甚至更低。另一类新兴的MRI造影剂使用超极化C-13来检测试剂，具有出色的灵敏度。这些超极化的C-13药剂可用于追踪新陈代谢并监测组织微环境的特征。总之，这些各种MRI造影剂为开发用于生物标志物检测的分子成像提供了极好的机会。

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