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Plant Molecular Farming: Much More than Medicines

机译:植物分子农业:远不止于医学

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摘要

Plants have emerged as commercially relevant production systems for pharmaceutical and nonpharmaceutical products. Currently, the commercially available nonpharmaceutical products outnumber the medical products of plant molecular farming, reflecting the shorter development times and lower regulatory burden of the former. Nonpharmaceutical products benefit more from the low costs and greater scalability of plant production systems without incurring the high costs associated with downstream processing and purification of pharmaceuticals. In this review, we explore the areas where plant-based manufacturing can make the greatest impact, focusing on commercialized products such as antibodies, enzymes, and growth factors that are used as research-grade or diagnostic reagents, cosmetic ingredients, and biosensors or biocatalysts. An outlook is provided on high-volume, low-margin proteins such as industrial enzymes that can be applied as crude extracts or unprocessed plant tissues in the feed, biofuel, and papermaking industries.
机译:植物已经成为与商业相关的药品和非药品产品生产系统。当前,市售的非药物产品超过了植物分子农业的医学产品,这反映了前者的开发时间较短且监管负担较低。非制药产品受益于植物生产系统的低成本和更大的可扩展性,而不会产生与药物的下游加工和纯化相关的高成本。在这篇综述中,我们探索了以植物为基础的制造能够产生最大影响的领域,重点研究了商品化产品,例如用作研究级或诊断试剂的抗体,酶和生长因子,化妆品成分以及生物传感器或生物催化剂。 。展望了大批量,低利润的蛋白质,例如工业酶,它们可以用作粗提物或未经加工的植物组织,用于饲料,生物燃料和造纸工业。

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