...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annual review of biophysics >Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for sigmoidal responses.
【24h】

Cooperativity in cellular biochemical processes: noise-enhanced sensitivity, fluctuating enzyme, bistability with nonlinear feedback, and other mechanisms for sigmoidal responses.

机译：细胞生化过程中的协同性：增强噪声的灵敏度，波动的酶，具有非线性反馈的双稳性和其他S型响应机制。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cooperativity in classical biophysics originates from molecular interactions; nonlinear feedbacks in biochemical networks regulate dynamics inside cells. Using stochastic reaction kinetic theory, we discuss cooperative transitions in cellular biochemical processes at both the macromolecular and the cellular levels. We show that fluctuation-enhanced sensitivity (stochastic focusing) shares an essential feature with the transition in a bistable system. The same theory explains zeroth-order ultrasensitivity with temporal cooperativity. Dynamic cooperativity in fluctuating enzyme (i.e., dynamic disorder), stochastic focusing, and the recently proposed stochastic binary decision all have a shared mechanism: They are generalizations of the hyperbolic response of Michaelis-Menten kinetics x/(K+x), with fluctuating K or stochastic x. Sigmoidal dependence on substrate concentration necessarily yields affinity amplification for competing ligands; both sigmoidal response and affinity amplification exhibit a square law. We suggest two important characteristics in a noise: its multimodal distribution structure and its temporal irreversibility. The former gives rise to self-organized complexity, and the latter contains useful, albeit hidden, free energy that can be utilized for biological functions. There could be structures and energy in biochemical fluctuations.
机译：古典生物物理学中的合作性源于分子相互作用。生化网络中的非线性反馈调节细胞内部的动力学。使用随机反应动力学理论，我们讨论了在大分子和细胞水平上细胞生化过程中的协同转变。我们表明，波动增强的灵敏度（随机聚焦）与双稳态系统中的过渡共享一个基本特征。相同的理论解释了零阶超敏感性和时间协同性。波动酶中的动态合作性（即动态障碍），随机聚焦以及最近提出的随机二元决策都有一个共同的机制：它们是迈克尔斯-门腾动力学x /（K + x）的双曲响应的一般化，具有波动性K或随机x。 S形对底物浓度的依赖性必定会产生竞争配体的亲和力扩增;乙状结肠反应和亲和力放大均表现出平方律。我们提出了噪声中的两个重要特征：其多峰分布结构及其时间不可逆性。前者引起自组织的复杂性，而后者包含有用的，尽管是隐藏的，可用于生物学功能的自由能。生化波动中可能存在结构和能量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号