Regulation of MHC class I assembly and peptide binding

Peaper DR; Cresswell P

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Regulation of MHC class I assembly and peptide binding

机译：调节MHC I类装配和肽结合

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Peptide binding to MHC class I molecules is a component of a folding and assembly process that occurs in the endoplasmic reticulum (ER) and uses both cellular chaperones and dedicated factors. The involvement of glycoprotein quality-control chaperones and cellular oxidoreductases in peptide binding has led to models that are gradually being refined. Some aspects of the peptide loading process (e.g., the biosynthesis and degradation of MHC class I complexes) conform to models of glycoprotein quality control, but other aspects (e.g., the formation of a stable disulfide-linked dimer between tapasin and ERp57) deviate from models of chaperone and oxidoreductase function. Here we review what is known about the intersection of glycoprotein folding, oxidative reactions, and MHC class I peptide loading, emphasizing events that occur in the ER and within the MHC class I peptide loading complex.

机译：与I类MHC分子结合的肽是内质网（ER）中发生的折叠和组装过程的组成部分，并且同时使用细胞伴侣和专用因子。糖蛋白质量控制伴侣和细胞氧化还原酶参与肽结合已导致模型逐渐完善。肽加载过程的某些方面（例如，MHC I类复合物的生物合成和降解）符合糖蛋白质量控制模型，但其他方面（例如，在塔帕胶和ERp57之间形成稳定的二硫键连接的二聚体）与伴侣和氧化还原酶功能的模型。在这里，我们回顾了有关糖蛋白折叠，氧化反应和MHC I类肽负载的交叉点的已知信息，重点介绍了在ER和MHC I类肽负载复合物中发生的事件。

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《Annual review of cell and developmental biology》 |2008年第0期|共26页
作者
Peaper DR; Cresswell P;
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正文语种 eng
中图分类细胞生物学;
关键词
Animals; Endoplasmic Reticulum metabolism; Genes; MHC Class I; Glycoproteins chemistry metabolism; Membrane Transport Proteins metabolism; Models; Molecular; Molecular Chaperones metabolism; Oxidation-Reduction; Peptides chemistry metabolism; Protein Conformation; Protein Disulfide-Isomerases chemistry metabolism; Protein Folding;

机译：动物;内质网代谢;基因;MHC I类;糖蛋白化学代谢;膜转运蛋白代谢;模型;分子;分子伴侣代谢;氧化还原;肽化学代谢;蛋白质构象;蛋白质二硫键异构酶化学代谢;蛋白质;

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专利

1. Regulation of MHC class I assembly and peptide binding [J] . Peaper DR, Cresswell P Annual review of cell and developmental biology . 2008,第0期

机译：调节MHC I类装配和肽结合
2. Dynamic Characteristics of a Peptide-Binding Groove of Human HLA-A2 Class I MHC Molecules: Normal Mode Analysis of the Antigen Peptide-Class I MHC Complex. [J] . Nojima H, Takeda Shitaka M, Kurihara Y, Chemical and Pharmaceutical Bulletin . 2002,第9期

机译：人HLA-A2 I类MHC分子的肽结合槽的动态特征：抗原I类MHC抗原肽的正常模式分析。
3. Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. [J] . W Chen, J McCluskey, S Rodda, The Journal of Experomental Medicine . 1993,第3期

机译：埋在主要组织相容性复合体（MHC）I类结合裂隙中的肽残基的变化会影响T细胞识别：I类MHC或结合的肽间接构象改变在确定T细胞识别中的可能作用。
4. Predicting Class-II MHC Binding Peptide Using Global Representation of Peptides [C] . Niu Yanqing 2011 International Conference on Intelligent Computation and Bio-Medical Instrumentation . 2011

机译：使用肽的整体表示预测II类MHC结合肽
5. The impact of HLA-DM on peptide binding to MHC class II. [D] . Templeton, Megan. 2016

机译：HLA-DM对肽与MHC II类结合的影响。
6. Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition [O] . 1993

机译：埋在主要组织相容性复合物（MHC）I类结合裂隙中的肽残基的变化会影响T细胞识别：I类MHC或结合肽的间接构象改变在确定T细胞识别中的可能作用
7. Dynamic Characteristics of a Peptide-Binding Groove of Human HLA-A2 Class I MHC Molecules: Normal Mode Analysis of the Antigen Peptide-Class I MHC Complex. [O] . Hiroyuki Nojima, Mayuko Takeda-Shitaka, Youji Kurihara, 2002

机译：人HLA-A2 I类MHC分子肽结合槽的动态特征：抗原肽-1类MHC复合物的正常模式分析。

Regulation of MHC class I assembly and peptide binding

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