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首页> 外文期刊>Annual review of cell and developmental biology >A decade of systems biology. [Review]
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A decade of systems biology. [Review]

机译：十年的系统生物学。 [评论]

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摘要

Systems biology provides a framework for assembling models of biological systems from systematic measurements. Since the field was first introduced a decade ago, considerable progress has been made in technologies for global cell measurement and in computational analyses of these data to map and model cell function. It has also greatly expanded into the translational sciences, with approaches pioneered in yeast now being applied to elucidate human development and disease. Here, we review the state of the field with a focus on four emerging applications of systems biology that are likely to be of particular importance during the decade to follow: (a) pathway-based biomarkers, (b) global genetic interaction maps, (c) systems approaches to identify disease genes, and (d) stem cell systems biology. We also cover recent advances in software tools that allow biologists to explore system-wide models and to formulate new hypotheses. The applications and methods covered in this review provide a set of prime exemplars useful to cell and developmental biologists wishing to apply systems approaches to areas of interest.
机译：系统生物学提供了一个框架，用于根据系统测量结果来组装生物系统模型。自从十年前首次引入该领域以来，在全球细胞测量技术以及这些数据的计算分析以映射和建模细胞功能方面取得了长足的进步。它也已极大地扩展到翻译科学领域，酵母中开创性的方法现已应用于阐明人类发育和疾病。在这里，我们重点研究系统生物学的四个新兴应用领域，这些应用在接下来的十年中可能尤为重要：（a）基于途径的生物标志物，（b）全球遗传相互作用图，（ c）鉴定疾病基因的系统方法，以及（d）干细胞系统生物学。我们还将介绍软件工具的最新进展，这些进展使生物学家能够探索系统范围的模型并提出新的假设。这篇综述中涵盖的应用和方法为希望将系统方法应用于关注领域的细胞和发育生物学家提供了一组主要的范例。

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