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首页> 外文期刊>Annual review of cell and developmental biology >Rolling cell adhesion. [Review]
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Rolling cell adhesion. [Review]

机译：滚动细胞粘附。 [评论]

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摘要

Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes, hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury. Rolling requires the rapid yet balanced formation and dissociation of adhesive bonds in the challenging environment of blood flow. This review explores how structurally distinct adhesion receptors interact through mechanically regulated kinetics with their ligands to meet these challenges. Remarkably, increasing force applied to adhesive bonds first prolongs their lifetimes (catch bonds) and then shortens their lifetimes (slip bonds). Catch bonds mediate the counterintuitive phenomenon of flow-enhanced rolling adhesion. Force-regulated disruptions of receptor interdomain or intradomain interactions remote from the ligand-binding surface generate catch bonds. Adhesion receptor dimerization, clustering in membrane domains, and interactions with the cytoskeleton modulate the forces applied to bonds. Both inside-out and outside-in cell signals regulate these processes.
机译：在血管表面滚动粘附是将循环白细胞，造血祖细胞或血小板募集到特定器官或感染或损伤部位的第一步。滚动需要在充满挑战的血流环境中迅速而平衡地形成和解离粘合键。这篇综述探讨了结构上不同的粘附受体如何通过机械调节的动力学与其配体相互作用来应对这些挑战。明显地，增加施加到粘合剂的力首先延长了它们的寿命（搭接），然后缩短了它们的寿命（滑动胶）。咬合介导了流动增强的滚动粘附的违反直觉的现象。远离配体结合表面的受力调节的受体域间或域内相互作用的破坏产生捕获键。粘附受体二聚化，在膜结构域中聚集以及与细胞骨架的相互作用调节施加于键的力。由内而外和由内而外的细胞信号均调节这些过程。

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