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首页> 外文期刊>Annual review of cell and developmental biology >Mechanical integration of actin and adhesion dynamics in cell migration. [Review]
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Mechanical integration of actin and adhesion dynamics in cell migration. [Review]

机译:肌动蛋白的机械整合和细胞迁移中的粘附动力学。 [评论]

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摘要

Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement, these processes must be spatiotemporally coordinated. To a large degree, the morphological changes and physical forces that occur during migration are generated by a dynamic filamentous actin (F-actin) cytoskeleton. Adhesion is regulated by dynamic assemblies of structural and signaling proteins that couple the F-actin cytoskeleton to the extracellular matrix. Here, we review current knowledge of the dynamic organization of the F-actin cytoskeleton in cell migration and the regulation of focal adhesion assembly and disassembly with an emphasis on how mechanical and biochemical signaling between these two systems regulate the coordination of physical processes in cell migration.
机译:定向细胞迁移是一个物理过程,需要细胞形状和对细胞外基质的粘附力发生巨大变化。为了有效移动,必须在时间上协调这些过程。在很大程度上,迁移过程中发生的形态变化和物理力是由动态丝状肌动蛋白(F-actin)细胞骨架产生的。粘附受到结构和信号蛋白动态装配的调节,这些蛋白将F-肌动蛋白的细胞骨架偶联至细胞外基质。在这里,我们回顾了有关F-肌动蛋白细胞骨架在细胞迁移中的动态组织以及粘着斑组装和拆卸的调节的当前知识,重点是这两个系统之间的机械和生化信号传导如何调节细胞迁移中物理过程的协调。

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