Novel research horizons for presenilins and -secretases in cell biology and disease. [Review]

De Strooper B; Annaert W

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Novel research horizons for presenilins and -secretases in cell biology and disease. [Review]

机译：细胞生物学和疾病中早老蛋白和分泌酶的新研究前景。 [评论]

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Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases consists of at least 60 different substrates. γ-Secretase is key to regulated intramembrane proteolysis, releasing protein fragments that potentially transduce signals at both sides of the cell membrane. Characteristic for this novel form of cellular signaling is its irreversible nature, providing direction to biological processes. We discuss recent insights in structure-function and assembly of the γ-secretase complexes and emerging insights in the regulation of the activity of these enzymes. This novel knowledge will help to develop better drugs for Alzheimer's disease and cancer. We critically evaluate literature that proposes presenilin functions outside of the γ-secretase complex.

机译：早老蛋白是较大的四聚体γ-分泌酶复合物的催化亚基。这些天冬氨酰蛋白酶的降解组由至少60种不同的底物组成。 γ-分泌酶是调节膜内蛋白水解，释放可能在细胞膜两侧传导信号的蛋白片段的关键。这种新形式的细胞信号传导的特征是其不可逆的性质，为生物学过程提供了指导。我们讨论了γ-分泌酶复合物的结构功能和组装方面的最新见解以及这些酶活性的调节方面的新见解。这种新颖的知识将有助于开发出更好的药物来治疗阿尔茨海默氏病和癌症。我们批判性地评估了提出γ-分泌酶复合物之外的早老素功能的文献。

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《Annual review of cell and developmental biology》 |2010年第1期|共26页
作者
De Strooper B; Annaert W;
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正文语种 eng
中图分类细胞生物学;
关键词
Alzheimer Disease; Amyloid Precursor Protein Secretases; Amyloid beta-Protein Precursor; Animals; Humans; Multiprotein Complexes; Presenilins; Signal Transduction;

机译：阿尔茨海默病;淀粉样前体蛋白分泌酶;淀粉样β-蛋白前体;动物;人类;多蛋白复合体;早老素;信号传导;

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1. Novel research horizons for presenilins and -secretases in cell biology and disease. [Review] [J] . De Strooper B, Annaert W Annual review of cell and developmental biology . 2010,第1期

机译：细胞生物学和疾病中早老蛋白和分泌酶的新研究前景。 [评论]
2. Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells. [J] . Alves Da Costa C, Ayral E, Hernandez JF, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2004,第4期

机译：早老素定向的γ-分泌酶抑制剂在表达早老素和早老素缺乏的细胞中触发胱天蛋白酶3活化。
3. Contribution of the Presenilins in the cell biology, structure and function of gamma-secretase [J] . Escamilla-Ayala Abril, Wouters Rosanne, Sannerud Ragna, Seminars in cell and developmental biology . 2020,第1期

机译：丙烯酸在γ-分泌酶的细胞生物学，结构和功能中的贡献
4. A Presenilin Dependent S3-Like gamma-Secretase Cleavage of the beta-Amyloid Precursor Protein [C] . H. Steiner, M. Sastre, G. Multhaup, Colloque M閐ecine et Recherche . 2002

机译：β-淀粉样蛋白前体蛋白的β-淀粉样蛋白前体蛋白的预腺苷依赖性S3样γ分泌酶切割
5. Dictyostelium discoideum possess a highly diverged presenilin/gamma-secretase that accurately processes human amyloid precursor protein and is required for growth and correct cell fate determination. [D] . McMains, Vanessa C. 2010

机译：盘基网柄菌拥有高度分化的早老素/γ-分泌酶，可准确加工人淀粉样蛋白前体蛋白，是生长和正确确定细胞命运所必需的。
6. Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments [O] . Xavier Meckler, Frédéric Checler 2016

机译：早老素1和早老素2靶标γ-分泌酶复合物可以区分不同的细胞室
7. Dictyostelium possesses highly diverged presenilin/γ-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/γ-secretase complex [O] . McMains, Vanessa C., Myre, Michael, Kreppel, Lisa, 2010

机译：Dictyostelium拥有高度分化的早老素/γ-分泌酶，可调节生长和细胞命运，并能准确处理人类APP：早老素/γ-分泌酶复合物功能研究的系统

Novel research horizons for presenilins and -secretases in cell biology and disease. [Review]

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