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首页> 外文期刊>The FEBS journal >Interplay between C-type lectin receptors and microRNAs in cellular homeostasis and immune response
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Interplay between C-type lectin receptors and microRNAs in cellular homeostasis and immune response

机译：C型凝集素受体和微小RORNA之间的相互作用在细胞稳态和免疫应答中

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摘要

C-type lectin receptors (CLRs) belong to the family of pattern recognition receptors (PRRs). They have a critical role to play in the regulation of a range of physiological functions including development, respiration, angiogenesis, inflammation, and immunity. CLRs can recognize distinct and conserved exogenous pathogen-associated as well as endogenous damage-associated molecular patterns. These interactions set off downstream signaling cascades, leading to the production of inflammatory mediators, activation of effector immune cells as well as regulation of the developmental and physiological homeostasis. CLR signaling must be tightly controlled to circumvent the excessive inflammatory burden and to maintain the cellular homeostasis. Recently, MicroRNAs (miRNAs) have been shown to be important regulators of expression of CLRs and their downstream signaling. The delicate balance between miRNAs and CLRs seems crucial in almost all aspects of multicellular life. Any dysregulations in the miRNA-CLR axes may lead to tumorigenesis or inflammatory diseases. Here, we present an overview of the current understanding of the central role of miRNAs in the regulation of CLR expression, profoundly impacting upon homeostasis and immunity, and thus, development of therapeutics against immune disorders.
机译：C型凝集素受体（CLR）属于模式识别受体（PRR）家族。它们在包括发育、呼吸、血管生成、炎症和免疫在内的一系列生理功能的调节中发挥着关键作用。CLR可以识别不同的、保守的外源性病原体相关分子模式以及内源性损伤相关分子模式。这些相互作用引发下游信号级联，导致炎症介质的产生、效应免疫细胞的激活以及发育和生理稳态的调节。必须严格控制CLR信号，以避免过度的炎症负担并维持细胞内稳态。最近，microRNA（miRNAs）已被证明是CLR表达及其下游信号传导的重要调节因子。在多细胞生命的几乎所有方面，miRNA和CLR之间的微妙平衡似乎至关重要。miRNA CLR轴的任何失调都可能导致肿瘤发生或炎症性疾病。在这里，我们概述了目前对miRNA在调节CLR表达中的中心作用的理解，它深刻地影响了体内平衡和免疫，从而影响了免疫疾病治疗的发展。

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