...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >Stress management intervention for primary prevention of hypertension: detailed results from Phase I of Trials of Hypertension Prevention (TOHP-I).
【24h】

Stress management intervention for primary prevention of hypertension: detailed results from Phase I of Trials of Hypertension Prevention (TOHP-I).

机译：预防高血压的压力管理干预措施：高血压预防试验第一阶段（TOHP-1）的详细结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: Stress Management Intervention (SMI) was one of seven nonpharmacologic approaches evaluated in Phase I Trials of Hypertension Prevention (TOHP-I) for efficacy in lowering diastolic blood pressure (BP) in healthy men and women aged 30 to 54 years with diastolic BP 80-89 mm Hg. METHODS: A total of 242 and 320 participants were randomized to SMI or an "assessment only" SMI Control, respectively, at four clinical centers. The SMI consisted of 37 contact hours in 21 group and two individual meetings over 18 months and included: training in four relaxation methods, techniques to reduce stress reactions, cognitive approaches, communication skills, time management, and anger management within a general problem-solving format. Standardized protocols detailed methods and timing for collecting BP, psychosocial measures, and urinary samples from both SMI and SMI Control participants. RESULTS: In intention-to-treat analyses, although significant baseline to termination BP reductions were observed in both groups, net differences between the SMI and SMI Control groups' BP changes (mean (95% CI)) were not significant: -0.82 (-1.86, 0.22) for diastolic BP, and -0.47 (-1.96, 1.01) for systolic BP. Extensive adherence sub-group analyses found one effect: a significant 1.36 mm Hg (p = 0.01) reduction in diastolic BP relative to SMI Controls at the end of the trial for SMI participants who completed 61% or more of intervention sessions. CONCLUSIONS: While the TOHP-I SMI was acceptable to participants as evident from high levels of session completion, the absence of demonstrated BP lowering efficacy in intention-to-treat analyses suggests that the TOHP-I SMI is an unlikely candidate for primary prevention of hypertension in a general population sample similar to study participants. The isolated finding of significant diastolic BP lowering in SMI participants with higher adherence provides very weak evidence of SMI BP lowering efficacy and may be a chance finding. Whether similar or other stress management interventions can produce significant BP lowering in populations selected for higher levels of BP, stress, or intervention adherence remains to be demonstrated.
机译：目的：压力管理干预（SMI）是高血压预防I期试验（TOHP-I）中评估的七种非药物方法之一，这些方法可有效降低30至54岁健康男性和女性舒张压的舒张压（BP） 80-89毫米汞柱方法：分别在四个临床中心将242名和320名参与者随机分为SMI或“仅评估” SMI对照。 SMI由21个小组的37个小时的联系时间和为期18个月的两次个人会议组成，包括：四种放松方法的培训，减少压力反应的技术，认知方法，沟通技巧，时间管理和在一般问题解决方案中的愤怒管理格式。标准化协议详细说明了从SMI和SMI控制参与者那里收集血压，心理社会测量和尿液样本的方法和时机。结果：在意向治疗分析中，尽管两组均观察到基线到终止BP的显着降低，但SMI和SMI对照组血压变化的净差异（均值（95％CI））不显着：-0.82（对于舒张压BP为-1.86，0.22），对于收缩压BP为-0.47（-1.96，1.01）。广泛的依从性亚组分析发现一种效果：对于完成了61％或更多干预活动的SMI参与者，在试验结束时，相对于SMI对照，舒张压BP显着降低1.36 mm Hg（p = 0.01）。结论：尽管从高水平的会话完成度来看，参与者可以接受TOHP-1 SMI，但在意向性治疗分析中由于没有证实的BP降低药效，这表明TOHP-1 SMI不太可能是预防乙型肝炎的主要方法。一般人群样本中的高血压与研究参与者相似。在依从性更高的SMI参与者中，舒张压明显降低的孤立发现为SMI BP降低功效提供了非常微弱的证据，可能是一个偶然的发现。在为较高的BP水平，压力或干预依从性而选择的人群中，类似或其他压力管理干预措施是否可以导致血压显着降低，尚待证实。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号