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首页> 外文期刊>Annals of epidemiology >A retrospective cohort study of implanted medical devices and selected chronic diseases in Medicare claims data.
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A retrospective cohort study of implanted medical devices and selected chronic diseases in Medicare claims data.

机译：Medicare索赔数据中对植入式医疗设备和某些慢性疾病的回顾性队列研究。

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PURPOSE: Several case-control studies have observed associations of implanted medical devices and certain connective-tissue and neurologic diseases. We reexamined these and other associations using cohort comparisons.METHODS: We compared the incidence of 52 diseases in several retrospective cohorts constructed from Medicare claims data. Six cohorts were defined by implantation of medical devices (silicone, metal bone or joint implants, breast implants, penile implants, pacemakers, artificial heart valves), and four comparison cohorts were defined by surgeries not involving implants. RESULTS: We observed associations that were generally consistent with previous reports, including associations of bone and joint implants with connective-tissue diseases, and an association of penile implants with idiopathic progressive neuropathy. We also observed associations of breast implants and pacemakers with connective-tissue diseases. CONCLUSIONS: For the most part, our study confirms our previous case-control results. Although confounding by presurgical conditions (such as diabetes) remains a plausible explanation of the findings, several associations are worthy of more detailed research.
机译：目的：一些病例对照研究已经观察到植入式医疗器械与某些结缔组织和神经系统疾病的关联。我们使用队列比较重新检查了这些和其他关联。方法：我们比较了根据Medicare索赔数据构建的若干回顾性队列中52种疾病的发生率。通过植入医疗器械（硅胶，金属骨或关节植入物，乳房植入物，阴茎植入物，起搏器，人造心脏瓣膜）定义了六个队列，并且通过不涉及植入物的手术定义了四个比较队列。结果：我们观察到的关联通常与以前的报道一致，包括骨骼和关节植入物与结缔组织疾病的关联，以及阴茎植入物与特发性进行性神经病的关联。我们还观察到了乳房植入物和起搏器与结缔组织疾病的关联。结论：在大多数情况下，我们的研究证实了我们以前的病例对照结果。尽管由于术前状况（例如糖尿病）而造成的混淆仍然是对这些发现的合理解释，但仍有一些协会值得进行更详细的研究。

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