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Uhambo - Twists and Turns on the Journey to an Efficacious HIV-1 Vaccine

机译:uhambo - 曲折到效果的HIV-1疫苗的旅程

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摘要

As we approach the 40th anniversary of the first reported cases of AIDS, the need for a vaccine to prevent HIV infection remains imperative. The absence of natural immunity to HIV, coupled with its genetic diversity and ability to establish infection that is resistant to host immunologic clearance, have impeded elucidation of immunologic mechanisms to protect against incident infection. Lacking immunologic markers of protection to guide vaccine development,(1) researchers have predicated large-scale efficacy trials on empirical approaches that seek to identify specific immune responses that are correlated with protection and build on the responses that are associated with even modest . . .
机译:在我们即将迎来首次报告的艾滋病病例40周年之际,预防艾滋病毒感染的疫苗仍然是当务之急。由于缺乏对艾滋病毒的自然免疫,加上其遗传多样性和建立抵抗宿主免疫清除的感染的能力,阻碍了对预防偶发感染的免疫机制的阐明。缺乏用于指导疫苗开发的免疫保护标记物,(1)研究人员预测了基于经验方法的大规模疗效试验,这些方法寻求识别与保护相关的特异性免疫反应,并建立在与即使是适度的。

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