Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine.

Haut LH; Ertl HC

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Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine.

机译：成功开发诱导T细胞的HIV-1疫苗的障碍。

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An efficacious vaccine to HIV-1 is direly needed to stem the global pandemic. Immunogens that elicit broadly cross-neutralizing antibodies to HIV-1 remain elusive, and thus, most HIV-1 vaccine efforts are focusing on induction of T cells. The notion that T cells can mediate protection against HIV-1 has been called into question by the failure of the STEP trial, which was designed to test this concept by the use of an E1-deleted Ad vaccine carrier. Lack of efficacy of the STEP trial vaccine underscores our limited knowledge about correlates of immune protection against HIV-1 and stresses the need for an enhanced commitment to basic research, including preclinical and clinical vaccine studies. In this review, we discuss known correlates of protection against HIV-1 and different vaccine strategies that have been or are being explored to induce such correlates, focusing on T cell-inducing vaccines and particularly on Ad vectors.

机译：迫切需要一种有效的HIV-1疫苗来阻止全球大流行。引起广泛交叉中和HIV-1抗体的免疫原仍然难以捉摸，因此，大多数HIV-1疫苗工作都集中在T细胞的诱导上。 STEP试验的失败使人们怀疑T细胞可以介导针对HIV-1的保护这一观点受到质疑，STEP试验旨在通过使用缺失E1的Ad疫苗载体来测试这一概念。 STEP试验疫苗缺乏疗效，突显了我们对HIV-1免疫保护相关知识的了解有限，并强调需要加强对基础研究（包括临床前和临床疫苗研究）的投入。在这篇综述中，我们讨论了针对HIV-1的已知保护关联以及已经或正在探索诱导这种关联的不同疫苗策略，重点是诱导T细胞的疫苗，尤其是Ad载体。

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2009年第4期|共15页
作者
Haut LH; Ertl HC;
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正文语种 eng
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1. Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine. [J] . Haut LH, Ertl HC Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2009,第4期

机译：成功开发诱导T细胞的HIV-1疫苗的障碍。
2. Obstacles to successful antiretroviral treatment of HIV-1 infection: problems & perspectives. [J] . Potter SJ, Chew CB, Steain M, The Indian journal of medical research. . 2004,第6期

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3. Preclinical development of BCG.HIVA(2auxo.int), harboring an integrative expression vector, for a HIV-TB Pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity [J] . Mahant Aakash, Saubi Narcis, Eto Yoshiki, Human vaccines & immunotherapeutics. . 2017,第8期

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4. Experimental development of efficacious task source relationships in interior lighting applications [C] . Siminovitch, M., Navvab, Industry Applications Society Annual Meeting, 1989., Conference Record of the 1989 IEEE . 1989

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5. Evolutionarily conserved cytotoxic T-lymphocyte epitopes on the human immunodeficiency virus and the feline immunodeficiency virus for an HIV-1 vaccine. [D] . Sanou, Missa Patrick. 2012

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6. Obstacles to the successful development of an efficacious T cell‐inducing HIV‐1 vaccine [O] . Larissa Herkenhoff Haut, Hildegund C. J. Ertl -1

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7. Preclinical development of BCG.HIVA(2auxo.int), harboring an integrative expression vector, for a HIV-TB pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity [O] . Mahant, A, Saubi, N, Eto, Y, 2017

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Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine.

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