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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >A Systematic Review andMeta-Analysisof Taste Dysfunction in Chronic Rhinosinusitis
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A Systematic Review andMeta-Analysisof Taste Dysfunction in Chronic Rhinosinusitis

机译：慢性鼻窦炎味道功能障碍的系统评价和荟萃分析

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Objectives Patients with chronic rhinosinusitis (CRS) often describe alterations in sense of taste. These complaints have historically been attributed to olfactory dysfunction; however, there is evidence of direct, objective, gustatory disturbances in the setting of CRS that are not thoroughly characterized. This study sought to investigate and summarize gustatory dysfunction experienced by patients with CRS. Methods PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases were reviewed following PRISMA guidelines. English language, original studies investigating objective taste in adult patients with CRS were included. A meta-analysis with inverse variance, random-effects model was performed. Results Of 2750 studies screened, 11 articles with 471 unique patients were included. Patients with CRS exhibit worse gustatory function compared to healthy controls (standardized mean difference 0.94 [95% CI, 0.44-1.45]). Hypogeusia was identified in 32/95 (33.7%) patients from three studies that used methods with a validated definition of hypogeusia. Older age, male gender, and smoking history were associated with taste dysfunction, while objective gustatory and olfactory dysfunction were not correlated. Subjective taste and quality of life measures were also not associated with objective taste. The impact of sinus surgery on objective taste is unclear. Conclusion Approximately 34% of patients with CRS experience hypogeusia. Neither olfactory function nor subjective taste were associated with objective gustatory function. Given the substantial prevalence of taste dysfunction patients with CRS, there is significant potential for growth in understanding of pathogenesis, impact on quality of life, and potential treatment strategies of taste impairment in the CRS patient population. Level of Evidence 1Laryngoscope, 2020
机译：目的慢性鼻窦炎（CRS）患者常描述味觉改变。这些投诉历来被认为是嗅觉障碍；然而，有证据表明，在CRS的设置中存在直接、客观、味觉障碍，这些障碍尚未完全确定。本研究旨在调查和总结CRS患者的味觉障碍。方法按照PRISMA指南对PubMed、EMBASE、Cochrane图书馆、科学网和Scopus数据库进行审查。英语，包括调查成人CRS患者客观味觉的原始研究。采用负方差随机效应模型进行荟萃分析。结果在筛选的2750项研究中，纳入了11篇文章和471名独特患者。与健康对照组相比，CRS患者的味觉功能更差（标准化平均差0.94[95%CI，0.44-1.45]）。在三项研究中，共有32/95（33.7%）患者出现了视力减退，这三项研究使用了经过验证的视力减退定义方法。年龄、男性和吸烟史与味觉障碍有关，而客观味觉和嗅觉障碍不相关。主观味觉和生活质量指标也与客观味觉无关。鼻窦手术对客观味觉的影响尚不清楚。结论约34%的CRS患者存在视力减退。嗅觉功能和主观味觉都与客观味觉功能无关。鉴于CRS患者味觉障碍的普遍性，CRS患者群体对味觉障碍的发病机制、对生活质量的影响以及潜在治疗策略的理解有很大的潜力。证据水平1拉林戈内窥镜，2020年

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