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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Chloroquine, Hydroxychloroquine and Hearing Loss: A Study in Systemic Lupus Erythematosus Patients
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Chloroquine, Hydroxychloroquine and Hearing Loss: A Study in Systemic Lupus Erythematosus Patients

机译：氯喹，羟基氯喹和听力损失：全身性狼疮患者的研究

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Objectives/Hypothesis Antimalarial drugs (chloroquine and hydroxychloroquine) are widely used for the treatment of systemic lupus erythematosus (SLE). However, these drugs may have side effects such as hearing loss. This study aimed to describe the hearing function in SLE patients using antimalarials. Secondarily, this study aimed to investigate whether SLE causes hearing loss and if there are any serological or clinical aspects of this diseases associated with inner ear damage. Study Design Cross-sectional study. Methods This study included 84 individuals (43 SLE patients and 41 controls) with audiometry and tympanometry tests. Epidemiological, clinical, serological, and treatment profiles of SLE patients were extracted from the charts. Results SLE patients had more sensorineural hearing loss than controls (23.2% vs. 0;P= .001). Pure-tone averages in SLE patients using antimalarials and not using antimalarials were similar (8.75 vs. 8.75;P= .63). At 8,000 Hz, antimalarial dug nonusers performed worse than users (10.00 vs. 22.50;P= .03). Tympanometry was normal in all participants. SLE serological and clinical profiles in patients with and without hearing loss were the same (allP= nonsignificant). Conclusions There is a high prevalence of hearing loss in SLE that is not affected by antimalarial drug use. Level of Evidence 3bLaryngoscope, 2020
机译：目的/假设抗疟药物（氯喹和羟氯喹）广泛用于治疗系统性红斑狼疮（SLE）。然而，这些药物可能有副作用，如听力损失。本研究旨在描述使用抗疟药物的SLE患者的听力功能。其次，本研究旨在调查SLE是否会导致听力损失，以及该疾病是否存在与内耳损伤相关的血清学或临床方面的问题。研究设计：横断面研究。方法对84名受试者（43名SLE患者和41名对照）进行听力测试和鼓室测试。从图表中提取了SLE患者的流行病学、临床、血清学和治疗概况。结果SLE患者的感音神经性听力损失比对照组多（23.2%比0；P=0.001）。使用抗疟药物和未使用抗疟药物的SLE患者的纯音平均值相似（分别为8.75和8.75；P=0.63）。在8000赫兹时，未使用抗疟药物的人的表现比使用抗疟药物的人差（10.00比22.50；P=0.03）。所有参与者的鼓室测量均正常。有听力损失和无听力损失患者的SLE血清学和临床特征相同（allP=无显著性）。结论SLE患者听力损失患病率较高，且不受抗疟药物使用的影响。证据等级3布莱恩戈普，2020年

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