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首页> 外文期刊>Annals of epidemiology >Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women.
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Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women.

机译：一群加拿大中年妇女的戒烟和肺癌死亡率。

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摘要

PURPOSE: To determine the impact of smoking cessation on lung cancer mortality among women. METHODS: Survival analysis is used to assess the effect of smoking cessation on lung cancer death in the dietary cohort of 49,165 women aged 40 to 59 years enrolled in the Canadian National Breast Screening Study. RESULTS: During an average of 10.3 years of follow-up, 106 women died of lung cancer. The risk of lung cancer mortality among women who quit before age 50 (HR=0.26; 95% CI, 0.13-0.55 among women who quit at ages 40-49) or quit in the previous 10 years (HR=0.39; 95% CI, 0.22-0.69) is substantially lower than the risk among current smokers. Women who quit after age 40 or have quit for less than 20 years are at substantially higher risk of lung cancer mortality compared with never smokers. Both duration of smoking cessation and age at quitting have independent effects on lung cancer mortality, after controlling for number of cigarettes smoked per day and number of years smoked, as well as other potential confounding variables. CONCLUSION: These findings suggest that programs and policies to promote early cessation of smoking and prevention of relapse should be a public health priority.
机译：目的：确定戒烟对女性肺癌死亡率的影响。方法：采用生存分析法评估了参加加拿大国家乳腺癌筛查研究的49,165名40至59岁妇女的饮食队列中戒烟对肺癌死亡的影响。结果：在平均10.3年的随访中，有106名妇女死于肺癌。在50岁之前戒烟的女性（HR = 0.26; 95％CI，在40-49岁戒烟女性的0.13-0.55）或在过去10年内戒烟的肺癌死亡风险（HR = 0.39; 95％CI （0.22-0.69）远低于当前吸烟者的风险。与从不吸烟的人相比，在40岁以后戒烟或少于20年戒烟的妇女罹患肺癌的风险要高得多。在控制了每天吸烟的次数和吸烟年数以及其他潜在的混杂变量之后，戒烟的持续时间和戒烟年龄均对肺癌死亡率具有独立的影响。结论：这些发现表明，促进及早戒烟和预防复发的计划和政策应作为公共卫生的重点。

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