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首页> 外文期刊>Annals of epidemiology >Depressive symptoms have an independent, gradient risk for coronary heart disease incidence in a random, population-based sample.
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Depressive symptoms have an independent, gradient risk for coronary heart disease incidence in a random, population-based sample.

机译：在基于人群的随机样本中，抑郁症状对冠心病的发病率具有独立的梯度风险。

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PURPOSE: Depression is a risk factor for incident coronary heart disease (CHD), and predicts poor prognosis for patients post-myocardial infarction (MI). Few population-based, prospective studies have tested a gradient risk for depressive symptoms on CHD incidence. METHODS: The sample (n=1302) was derived from the Nova Scotia Health Survey-1995 (NSHS95), an age- and sex-stratified, random, population-based health survey. All subjects were 45 years or older, free of overt CHD at baseline, and completed the Center for Epidemiological Studies-Depression (CES-D) scale. Covariates included age, sex, body mass index, physical activity level, family history of premature CHD, diastolic blood pressure, lipids, smoking, alcohol use, diabetes, and education level. For the 4 years following NSHS95, MI-related hospitalizations (ICD-9-CM code 410) and CHD-related deaths (ICD-9-CM codes 410-414) were extracted from the provincial, universal healthcare registry. RESULTS: Fifty-two participants experienced a CHD event.A one standard-deviation increase in CES-D score was associated with a 1.32 hazard risk (confidence interval, 1.01-1.71) of CHD events, controlling for established CHD risk factors. CONCLUSIONS: An independent, gradient association between depression and incident CHD was detected in a population-based sample with complete 4-year CHD data. This evidence supports the value of investigating mechanisms linking depression and CHD.
机译：目的：抑郁症是发生冠心病（CHD）的危险因素，并预测心肌梗死（MI）患者的预后不良。很少有基于人群的前瞻性研究测试冠心病发病率的抑郁症状梯度风险。方法：样本（n = 1302）来自新斯科舍省健康调查-1995（NSHS95），这是一项按年龄和性别分层，基于人群的随机健康调查。所有受试者均年满45岁或以上，基线时无明显冠心病，并完成了抑郁症流行病学研究中心（CES-D）量表。协变量包括年龄，性别，体重指数，体育活动水平，早产冠心病家族史，舒张压，脂质，吸烟，饮酒，糖尿病和教育程度。在NSHS95之后的4年中，从省级全民医疗注册中心提取了与MI相关的住院治疗（ICD-9-CM代码410）和与CHD相关的死亡（ICD-9-CM代码410-414）。结果：52名参与者经历了冠心病事件.CES-D得分增加1个标准差与1.32冠心病事件的危险风险（置信区间为1.01-1.71）相关，以控制已确定的冠心病危险因素。结论：在具有完整的4年冠心病数据的人群样本中，抑郁与入射冠心病之间存在独立的梯度关联。该证据支持将抑郁症和冠心病联系起来的研究机制的价值。

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