Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story

Berndt Nikolaus; Kolbe Erik; Gajowski Robert; Eckstein Johannes; Ott Fritzi; Meierhofer David; Holzhuetter Hermann-Georg; Matz-Soja Madlen

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Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story

机译：小鼠肝脏代谢区划的功能后果：旧故事见解

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Background and Aims Zone-dependent differences in expression of metabolic enzymes along the portocentral axis of the acinus are a long-known feature of liver metabolism. A prominent example is the preferential localization of the enzyme, glutamine synthetase, in pericentral hepatocytes, where it converts potentially toxic ammonia to the valuable amino acid, glutamine. However, with the exception of a few key regulatory enzymes, a comprehensive and quantitative assessment of zonal differences in the abundance of metabolic enzymes and, much more important, an estimation of the associated functional differences between portal and central hepatocytes is missing thus far.

机译：背景和目的：腺泡门中心轴代谢酶表达的区域依赖性差异是肝脏代谢的一个众所周知的特征。一个突出的例子是谷氨酰胺合成酶在中央周围肝细胞中的优先定位，它将潜在毒性的氨转化为有价值的氨基酸谷氨酰胺。然而，除了一些关键的调节酶外，到目前为止，还没有对代谢酶丰度的分区差异进行全面和定量的评估，更重要的是，对门脉肝细胞和中央肝细胞之间相关功能差异的估计。

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来源
《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2021年第2期|共16页
作者
Berndt Nikolaus; Kolbe Erik; Gajowski Robert; Eckstein Johannes; Ott Fritzi; Meierhofer David; Holzhuetter Hermann-Georg; Matz-Soja Madlen;
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作者单位

Charite Univ Med Berlin Berlin Germany;

Univ Leipzig Fac Med Rudolf Schonheimer Inst Biochem Leipzig Germany;

Max Planck Inst Mol Genet Berlin Germany;

Charite Univ Med Berlin Berlin Germany;

Univ Leipzig Fac Med Rudolf Schonheimer Inst Biochem Leipzig Germany;

Max Planck Inst Mol Genet Berlin Germany;

Charite Univ Med Berlin Berlin Germany;

Univ Leipzig Fac Med Rudolf Schonheimer Inst Biochem Leipzig Germany;

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正文语种 eng
中图分类消化系及腹部疾病;
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Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story

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