Fast multipoint immobilization of lipase through chiral L-proline on a MOF as a chiral bioreactor

Lirio Stephen; Shih Yung-Han; So Pamela Berilyn; Liu Li-Hao; Yen Yun-Ting; Furukawa Shuhei; Liu Wan-Ling; Huang Hsi-Ya; Lin Chia-Her

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Fast multipoint immobilization of lipase through chiral L-proline on a MOF as a chiral bioreactor

机译：脂肪酶通过手性L-脯氨酸的快速多点固定，作为手性生物反应器

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In this paper, we describe the facile preparation of a chiral catalyst by the combination of the amino acid, L-proline (Pro), and the enzyme, porcine pancreas lipase (PPL), immobilized on a microporous metal-organic framework (PPL-Pro@MOF). The multipoint immobilization of PPL onto the MOF is made possible with the aid of Pro, which also provided a chiral environment for enhanced enantioselectivity. The application of the microporous MOF is pivotal in maintaining the catalytic activity of PPL, wherein it prevented the leaching of Pro during the catalytic reaction, leading to the enhanced activity of PPL. The prepared biocatalyst was applied in asymmetric carbon-carbon bond formation, demonstrating the potential of this simple approach for chemical transformations.

机译：在本文中，我们描述了将氨基酸L-脯氨酸（Pro）和固定在微孔金属有机骨架（PPL）上的酶猪胰脏脂肪酶（PPL）结合起来制备手性催化剂的简易方法-Pro@MOF)在Pro的帮助下，PPL在MOF上的多点固定化成为可能，这也为提高对映选择性提供了手性环境。微孔MOF的应用对于保持PPL的催化活性至关重要，其中它防止了催化反应期间Pro的浸出，从而提高了PPL的活性。所制备的生物催化剂用于不对称碳-碳键的形成，证明了这种简单的化学转化方法的潜力。

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《Dalton transactions: An international journal of inorganic chemistry》 |2021年第5期|共8页
作者
Lirio Stephen; Shih Yung-Han; So Pamela Berilyn; Liu Li-Hao; Yen Yun-Ting; Furukawa Shuhei; Liu Wan-Ling; Huang Hsi-Ya; Lin Chia-Her;
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Chung Yuan Christian Univ Dept Chem 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Chung Yuan Christian Univ Dept Chem 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Chung Yuan Christian Univ Dept Chem 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Chung Yuan Christian Univ Dept Chem 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Chung Yuan Christian Univ Dept Chem 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Kyoto Univ Inst Integrated Cell Mat Sci WPI iCeMS Sakyo Ku Kyoto 6068501 Japan;

Chung Yuan Christian Univ Coll Sci 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Chung Yuan Christian Univ Dept Chem 200 Zhongbei Rd Taoyuan 32023 Taiwan;

Natl Taiwan Normal Univ Dept Chem 88 Sec 4 Ting Chow Rd Taipei 11676 Taiwan;

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正文语种 eng
中图分类化学;无机化学;
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2. Modification of Chiral Stationary Phases with L-Proline as a Selector for Ligand-exchange Chromatography via Introducing Hydrophobic Groups [J] . SHI Hong-yu, ZHANG Hai-zhu, LONG Yuan-de, 高等学校化学研究：英文版 . 2009,第006期
3. Modification of Chiral Stationary Phases with L-Proline as a Selector for Ligand-exchange Chromatography via Introducing Hydrophobic Groups [J] . SHI Hong-yu, ZHANG Hai-zhu, LONG Yuan-de, 高等学校化学研究（英文版） . 2009,第006期
4. Fast Multipoint Immobilized MOF Bioreactor [J] . Wan-Ling Liu, Cheng-You Wu, Chien-Yu Chen, Chemistry: A European journal . 2014,第29期

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机译：快速多点固定MOF生物反应器
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Fast multipoint immobilization of lipase through chiral L-proline on a MOF as a chiral bioreactor

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