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首页> 外文期刊>Annals of epidemiology >Relationship between Lifetime Alcohol Consumption and Helicobacter Pylori Infection.
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Relationship between Lifetime Alcohol Consumption and Helicobacter Pylori Infection.

机译：终生饮酒与幽门螺杆菌感染之间的关系。

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PURPOSE: Several studies have demonstrated an inverse relationship between current moderate alcohol consumption and Helicobacter pylori (H. pylori) infection suggesting that alcohol consumption may facilitate elimination of this chronic infection. The aim of this study was to further explore this hypothesis by taking lifetime alcohol consumption, which may be a better marker of the relevant exposure than current alcohol consumption, into account. METHODS: A total of 1206 patients between 30 and 70 years of age who underwent in-patient rehabilitation due to coronary heart disease were included in a cross sectional study carried out between January 1999 and April 2000. Participants provided information on average amount of alcohol consumed during past 12 months as well as during lifetime. H. pylori infection status was measured by serum immunoglobulin G antibodies. RESULTS: There was an inverse non-linear relation between amount of current alcohol consumption and H. pylori seroprevalence. By contrast, wefound an inverse dose-response relationship between lifetime alcohol consumption and H. pylori seroprevalence with the strongest risk reduction among subjects who had consumed more than 500,000 g of alcohol during life (adjusted odds ratio, 0.65; 95% confidence interval, 0.42-1.00). CONCLUSION: Our analysis supports the hypothesis that alcohol consumption may facilitate elimination of H. pylori infection among adults.
机译：目的：几项研究表明当前适度饮酒与幽门螺杆菌感染之间存在反比关系，这表明饮酒可促进消除这种慢性感染。这项研究的目的是通过考虑终生饮酒量来进一步探讨这一假设，考虑到终生饮酒量可能比当前饮酒量更好地反映了相关暴露。方法：1999年1月至2000年4月进行的横断面研究中纳入了1206名30至70岁的因冠心病住院康复的患者。参与者提供了平均饮酒量的信息在过去的12个月以及一生中。幽门螺杆菌感染状况通过血清免疫球蛋白G抗体测定。结果：当前饮酒量与幽门螺杆菌血清阳性率之间存在非线性反比关系。相比之下，我们发现终生饮酒与幽门螺杆菌血清阳性之间存在剂量-反比关系，在一生中饮酒超过500,000 g的受试者中风险降低幅度最大（调整后的优势比为0.65; 95％置信区间为0.42） -1.00）。结论：我们的分析支持以下假设：饮酒可以促进成年人消除幽门螺杆菌感染。

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