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首页> 外文期刊>Annals of epidemiology >Social, Behavioral, and Metabolic Determinants of Plasma Viscosity in the Whitehall II Study.
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Social, Behavioral, and Metabolic Determinants of Plasma Viscosity in the Whitehall II Study.

机译：白厅II研究中血浆粘度的社会，行为和代谢决定因素。

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PURPOSE: To examine the social, biological, and metabolic associations of plasma viscosity in a large epidemiological study. METHODS: Plasma viscosity was measured from 4548 men and 1837 women that took part in the fifth phase of the Whitehall II Study (1997-1999). Employment grade was used as a measure of social position. RESULTS: A strong inverse relation between employment grade and plasma viscosity was evident (p < 0.0001). This employment grade gradient was apparent overall, and among non-smokers and when participants with poor health were removed from the analyses. Plasma viscosity was associated with a number of biological factors that are themselves socially determined, including fibrinogen (p < 0.001), triglycerides (p < 0.001), fasting insulin (p < 0.001), and height (p < 0.001). Associations with smoking and alcohol intake were apparent in women. In men a U-shaped curve was apparent such that those drinking between 11 and 24 units/week had the lowest plasma viscosity. Alcohol intake, physical activity, and smoking explained 18% of the grade gradient in men and 40% in women while the biological factors examined accounted for 35% in men and 40% in women. CONCLUSION: There is a grade gradient in plasma viscosity which was not fully explained by health related behaviors or measured risk factors for CHD. These data suggest that additional factors that contribute to the rheological properties of plasma may contribute to the explanation for social inequalities in cardiovascular disease.
机译：目的：在大型流行病学研究中检查血浆粘度的社会，生物学和代谢关联。方法：从参加白厅II研究（1997-1999）第五阶段的4548名男性和1837名女性中测量血浆粘度。就业等级被用来衡量社会地位。结果：就业等级与血浆粘度之间存在明显的负相关关系（p <0.0001）。总体上，以及在非吸烟者中以及从分析中剔除健康状况较差的参与者时，这种就业等级梯度是明显的。血浆粘度与许多由社会决定的生物学因素有关，包括纤维蛋白原（p <0.001），甘油三酸酯（p <0.001），空腹胰岛素（p <0.001）和身高（p <0.001）。女性明显与吸烟和饮酒有关。在男性中，U形曲线很明显，因此每周饮酒11至24单位的人血浆粘度最低。饮酒，体育锻炼和吸烟解释了男性18％的梯度变化和女性40％的梯度变化，而生物学因素占男性的35％和女性的40％。结论：血浆粘度存在梯度梯度，但不能通过健康相关行为或冠心病的危险因素来完全解释。这些数据表明，有助于血浆流变特性的其他因素可能有助于解释心血管疾病中的社会不平等。

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