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首页> 外文期刊>Annals of epidemiology >Animal fat consumption and pancreatic cancer incidence: evidence of interaction with cigarette smoking.
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Animal fat consumption and pancreatic cancer incidence: evidence of interaction with cigarette smoking.

机译：动物脂肪消耗和胰腺癌的发病率：与吸烟相互作用的证据。

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PURPOSE: A large difference in fat intake and pancreatic cancer incidence exists among populations worldwide. This study investigated the relation between fat consumption and pancreatic cancer risk at the population level. METHODS: Fat consumption data for nine periods (1964-1994) and age-standardized pancreatic cancer incidence data for five periods (1973-1997) in 35 countries were derived from the Food and Agriculture Organization and World Health Organization, respectively. RESULTS: A significant positive correlation was found between animal fat consumption and pancreatic cancer incidence in all periods examined (r=0.40-0.74, p=0.021 to < 0.0001 in men and r=0.50-0.66, p=0.01 to 0.0001 in women). After adjustment for smoking and other confounders, animal fat consumption in all nine periods considered was still significantly and positively associated with pancreatic cancer incidence in the 1993 to 1997 period in both sexes. The stratified analysis showed that this association was significant only in countries with below median level of smoking (< 2273 cigarettes/adult/year). A similar but less pronounced effect was observed for total fat consumption. CONCLUSIONS: The consumption of fat, especially animal fat, was associated with an increased risk of pancreatic cancer and this association was modified by levels of cigarette smoking.
机译：目的：全球人群之间脂肪摄入和胰腺癌的发病率存在很大差异。这项研究在人群水平上研究了脂肪消耗与胰腺癌风险之间的关系。方法：分别来自粮食及农业组织和世界卫生组织的35个国家的9个时期（1964-1994年）的脂肪消耗数据和5个时期（1973-1997年）的年龄标准化胰腺癌发病率数据。结果：在所有检查的时期内，动物脂肪摄入与胰腺癌发生率之间均呈显着正相关（男性r = 0.40-0.74，p = 0.021至<0.0001，女性r = 0.50-0.66，p = 0.01至0.0001） 。在对吸烟和其他混杂因素进行调整之后，在所有这9个时期中，动物脂肪的摄入在两性之间均与1993年至1997年期间胰腺癌的发病率仍显着正相关。分层分析表明，这种关联性仅在中位数吸烟水平低于（<2273支香烟/成人/年）的国家中才有意义。对于总脂肪消耗，观察到类似但不太明显的作用。结论：脂肪，特别是动物脂肪的消耗与胰腺癌的风险增加有关，并且这种联系因吸烟水平而改变。

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