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首页> 外文期刊>Annals of epidemiology >Reproductive risk factors for epithelial ovarian cancer according to histologic type and invasiveness.
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Reproductive risk factors for epithelial ovarian cancer according to histologic type and invasiveness.

机译：根据组织学类型和侵袭性，上皮性卵巢癌的生殖危险因素。

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PURPOSE: Differences in histology among the subtypes of epithelial ovarian tumors suggest possible differences in their etiologies. We examined reproductive risk factors for epithelial ovarian cancer according to histologic subtype and tumor invasiveness. METHODS: We conducted a population-based, case-control study of associations between reproductive risk factors and epithelial ovarian cancer in the Delaware Valley from 1994 to 1998. Cases age 20 to 69 years with a recent diagnosis of epithelial ovarian cancer (n = 767) were compared to community controls (n = 1367) frequency matched by age. RESULTS: With few exceptions, we found significant risk reduction for each histologic subtype of epithelial ovarian cancer by using oral contraceptive, bearing children, and having a tubal ligation; for each subtype, there was significant increased risk associated with a family history of the disease. There were no significant differences among histologic subtypes in the magnitude of the odds ratios for OC use, parity, breastfeeding, tubal ligation, hysterectomy, family history of breast or ovarian cancer, use of noncontraceptive estrogens, age at menarche, and age at menopause. There were also few differences between invasive and borderline tumors, except that women with borderline tumors were significantly younger than women with invasive disease (44.7 years vs. 52.0 years, p < 0.001). Among serous tumors only, women with borderline tumors were more likely to use oral contraceptives than women with invasive tumors (OR = 2.28 95% CI 1.20-4.35). CONCLUSION: The results of this study suggest that reproductive risk factors do not differ among histologic subtypes of epithelial ovarian cancers.
机译：目的：上皮性卵巢肿瘤亚型之间的组织学差异表明其病因可能存在差异。我们根据组织学亚型和肿瘤浸润性检查了上皮性卵巢癌的生殖危险因素。方法：我们于1994年至1998年在特拉华河谷进行了一项基于人群的病例对照研究，研究了生殖危险因素与上皮性卵巢癌之间的关联。年龄在20至69岁之间，最近被诊断出上皮性卵巢癌（n = 767） ）与按年龄匹配的社区对照组（n = 1367）进行比较。结果：除少数例外，我们发现使用口服避孕药，有生育能力的孩子并进行输卵管结扎术可显着降低每种上皮性卵巢癌组织学亚型的风险。对于每种亚型，与该疾病的家族史相关的风险显着增加。组织学亚型之间的OC使用率，胎次，母乳喂养，输卵管结扎，子宫切除，乳腺癌或卵巢癌家族史，使用非避孕雌激素，初潮年龄和绝经年龄的比值比值之间无显着差异。浸润性和交界性肿瘤之间也几乎没有差异，除了交界性肿瘤的女性比浸润性疾病的女性明显年轻（44.7岁比52.0岁，p <0.001）。仅在浆液性肿瘤中，具有交界性肿瘤的女性比具有浸润性肿瘤的女性更有可能使用口服避孕药（OR = 2.28 95％CI 1.20-4.35）。结论：这项研究的结果表明，生殖危险因素在上皮性卵巢癌的组织学亚型之间没有差异。

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