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首页> 外文期刊>Annals of epidemiology >Cigarette smoking and risk of bladder, pancreas, kidney, and colorectal cancers in Iowa.
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Cigarette smoking and risk of bladder, pancreas, kidney, and colorectal cancers in Iowa.

机译：爱荷华州的吸烟和膀胱癌，胰腺癌，肾癌和大肠癌的风险。

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PURPOSE: Although there are numerous reports on the effects of cigarette smoking and cancer, they have infrequently compared risks at more than one cancer site after multivariate adjustment. We analyzed data from a population-based case-control study that included five anatomic sites to evaluate the association between cigarette smoking and each cancer site and to rank the associations by site. METHODS: Study respondents included 1452 bladder, 406 kidney, 376 pancreatic, 685 colon, and 655 rectal cancer cases, as well as 2434 population controls. A self-administered questionnaire was used to collect information on cigarette smoking and other potential confounders including occupation, drinking water source, and dietary practices. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), after adjustment for age, total energy intake, and other site- and sex-specific confounders. RESULTS: In both sexes, cigarette smoking (ever vs. never) was associated with risk of bladder cancer (OR = 2.5; 95% CI, 2.0-3.1 for males; OR = 2.7; 2.0-3.6 for females) and pancreatic cancer (OR = 1.8; 1.2-2.8 for males; OR = 2.1; 1.4-3.1 for females). Cigarette smoking also increased the risk of kidney cancer among males (OR = 1.8; 1.3-2.7), and to a lesser degree, among females (OR = 1.2; 0.8-1.8). No association was found for colon or rectal cancer in either sex. CONCLUSIONS: Cigarette smoking increased the risk of bladder, kidney, and pancreatic cancer in men and women. The rankings of multivariate-adjusted ORs from highest to lowest were bladder, pancreas, kidney, and colorectum, with little difference between men and women.
机译：目的：尽管有许多关于吸烟和癌症影响的报道，但在进行多变量调整后，他们很少比较一个以上癌症部位的风险。我们分析了一项基于人群的病例对照研究的数据，该研究包括五个解剖部位，以评估吸烟与每个癌症部位之间的关联，并按部位对关联进行排名。方法：研究对象包括1452例膀胱，406例肾脏，376例胰腺，685例结肠癌和655例直肠癌病例，以及2434例人群对照。使用自我管理的调查表收集有关吸烟和其他潜在混杂因素的信息，包括职业，饮用水源和饮食习惯。在调整了年龄，总能量摄入以及其他特定地点和性别混杂因素后，使用逻辑回归模型计算比值比（OR）和95％置信区间（CI）。结果：在男女中，吸烟（从无到有）与膀胱癌（OR = 2.5; 95％CI，男性为2​​.0-3.1; OR = 2.7;女性为2.0-3.6）和胰腺癌的风险相关。 OR = 1.8;男性为1.2-2.8; OR = 2.1;女性为1.4-3.1）。吸烟也增加了男性患肾癌的风险（OR = 1.8; 1.3-2.7），而女性患肾癌的风险较小（OR = 1.2; 0.8-1.8）。男女之间未发现结肠癌或直肠癌的相关性。结论：吸烟会增加男性和女性患膀胱癌，肾癌和胰腺癌的风险。从最高到最低的多元调整OR的排名是膀胱，胰腺，肾脏和结肠直肠，男女之间差异不大。

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