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首页> 外文期刊>Annals of epidemiology >Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas.
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Seroprevalence of Kaposi's sarcoma-associated herpesvirus infection among blood donors from Texas.

机译：在得克萨斯州的献血者中卡波西氏肉瘤相关疱疹病毒感染的血清阳性率。

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PURPOSE: Kaposi's sarcoma-associated herpesvirus (KSHV), a gammaherpesvirus recently discovered among AIDS patients with Kaposi's sarcoma, is a potential candidate for screening in blood and plasma donors. While a number of studies have assessed KSHV infection among U.S. blood donors, larger-scale population-based studies would be necessary to develop more refined estimates of the magnitude and variation of KSHV infection across different geographic regions of the U.S. blood supply. The goal of the present study, therefore, was to determine the seroprevalence of KSHV infection and to assess demographic correlates of KSHV infection among south Texas blood donors. METHODS: KSHV infection was determined using specific serologic assays that measure antibodies to KSHV latent and lytic antigens. RESULTS: The overall seroprevalence of KSHV in Texas blood donors (15.0%) is substantially higher than previously reported among blood donor and general population samples in the United States. This high rate of KSHV infection persisted across most of the sociodemographic subgroups under study but was particularly elevated among participants with less than a high school education. The infection rate also increased linearly with age. CONCLUSIONS: The elevated infection rate reported in the present study suggests that screening methods to detect KSHV infection in blood donors should be considered. In view of the etiologic role of KSHV for several malignancies, it would be important for future studies to directly assess the risk of KSHV transmission via blood transfusion.
机译：目的：卡波西氏肉瘤相关疱疹病毒（KSHV）是一种在爱滋病患者卡波西氏肉瘤中最近发现的γ疱疹病毒，是筛查血液和血浆供体的潜在候选者。尽管许多研究已经评估了美国献血者中的KSHV感染，但仍需要进行大规模的基于人群的研究，以更精确地估算出美国血液供应不同地区的KSHV感染的程度和变化。因此，本研究的目的是确定南德克萨斯州献血者中KSHV感染的血清阳性率，并评估KSHV感染的人口统计学相关性。方法：使用特定的血清学测定法测定KSHV感染，该方法可检测针对KSHV潜伏性和裂解性抗原的抗体。结果：德克萨斯州献血者中KSHV的总体血清阳性率（15.0％）大大高于先前在美国的献血者和普通人群样本中报告的水平。在所研究的大多数社会人口学亚组中，如此高的KSHV感染率一直持续存在，但在高中以下文化程度的参与者中尤为明显。感染率也随着年龄线性增加。结论：本研究报告的感染率升高提示应考虑采用筛查方法检测献血者中KSHV感染。考虑到KSHV在几种恶性肿瘤中的病因学作用，直接评估通过输血传播KSHV的风险对未来的研究很重要。

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