• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >Helicobacter pylori prevalence and CagA status among children in two counties of China with high and low risks of gastric cancer.
【24h】

Helicobacter pylori prevalence and CagA status among children in two counties of China with high and low risks of gastric cancer.

机译：中国两个县胃癌高风险和低风险儿童的幽门螺杆菌患病率和CagA状况。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Studies in adult populations in selected countries with widely varying rates of gastric cancer have shown a weak correlation between gastric cancer mortality rates and the prevalence of CagA+ strains of H. pylori. However, only limited data are available in ethnically homogenous populations with varying rates in the same region. METHODS; We compared the prevalence of H. pylori in general and of CagA+ strains in particular among children in Shandong Province, China in areas at high (Linqu County) and low risk (Cangshan County) of gastric cancer. H. pylori status among children aged 3 to 12 years was determined by 13C-UBT, and CagA status was determined by enzyme-linked immunosorbent assay (ELISA). Because of the difficulty in obtaining blood from young children aged 3 to 4 years and from some children aged 5 years, CagA status was determined among part of children 5 years old and children 6 to 12 years old. RESULTS; Among 98 children aged 3 to 12 years in Linqu, 68 (69.4%) was H. pylori-positive, as compared with 29 (28.7%) among 101 children in Cangshan. Among children positive for 13C-UBT, the proportion of the CagA+ strains were identified was 46 (88.5%) of 52 in Linqu and 13 (81.3%) of 16 in Cangshan, respectively. CONCLUSIONS: The prevalence of H. pylori was nearly three times higher among children in Linqu than in Cangshan, which may contribute to the large differential in gastric cancer rates for two neighboring populations in Shandong Province.
机译：背景：在某些胃癌发病率差异很大的国家中，成年人群的研究表明，胃癌死亡率与幽门螺杆菌CagA +菌株的流行之间存在弱相关性。但是，在同一地区，具有不同比率的种族同质人口中只有有限的数据。方法;我们比较了中国山东省胃癌高发地区（临qu县）和低危地区（苍山县）儿童中一般幽门螺杆菌的流行率，尤其是CagA +菌株的患病率。通过13C-UBT确定3至12岁儿童的幽门螺杆菌状态，并通过酶联免疫吸附测定（ELISA）确定CagA状态。由于难以从3至4岁的幼儿和一些5岁的儿童中获取血液，因此在部分5岁的儿童和6至12岁的儿童中确定了CagA的状态。结果;在临qu市的98名3至12岁的儿童中，有68名（69.4％）为幽门螺杆菌阳性，而苍山的101名儿童中有29名（28.7％）。在13C-UBT阳性的儿童中，鉴定出的CagA +菌株比例分别为临曲市52例中的46（88.5％）和苍山16中13例（81.3％）。结论：临qu市儿童幽门螺杆菌患病率比苍山地区高近三倍，这可能是山东省两个邻近人群胃癌发病率差异较大的原因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号