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Cyclodextrin News Retrospective

机译:Cyclodextrin新闻回顾展

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摘要

10 years ago, the editorial of Cyclodextrin News dealt with the application of differently methylated BCD derivatives (and their cholesterol complexes) in controlled manipulation of membrane cholesterol content. The reported major findings were the followings: - Decreasing the degree of methylation resulted in decreased solubilization of cholesterol, - Comparing different purity grades of DIMEB it was observed that the isomer purity had hardly any influence on cholesterol solubilization and the effects on cell viability were also very similar, - Ionic, “Second generation” CD derivatives obtained by further derivatization of methylated CDs showed much lower cholesterol solubilizing effect than their parent methylated CDs, nevertheless higher than the related ionic CD derivatives.
机译:10年前,环糊精新闻的社论涉及不同甲基化的BCD衍生物(及其胆固醇复合物)在受控的膜胆固醇含量的操纵中的应用。 报道的主要发现是: - 降低甲基化程度导致胆固醇的溶解度降低, - 比较了dimeb的不同纯度等级,观察到异构体纯度几乎没有任何对胆固醇溶解的影响,并且对细胞的可通过影响也是如此 非常相似的 - 通过甲基化CD的进一步衍生化获得的离子“第二代” CD衍生物比其母甲基化的CDs溶解效果低得多,但仍高于相关的离子CD衍生物。

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