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首页> 外文期刊>Annals of epidemiology >Determinants of age at menarche and time to menstrual cycle regularity in the French E3N cohort
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Determinants of age at menarche and time to menstrual cycle regularity in the French E3N cohort

机译：法国E3N队列的初潮年龄和月经周期规律的决定因素

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Purpose: Early menarche has been associated with a greater risk of several major chronic diseases. Although largely genetically determined, age at menarche also has been related to environmental and lifestyle factors. Methods: Using linear regression models, we explored simultaneously several pre- and postnatal factors as potential determinants of age at menarche and time to menstrual cycle regularity in 96,493 women participating, since 1990, in the French E3N prospective cohort. Results: Younger age at recruitment, greater father's income index, urban birth place, greater birth length, and larger body silhouette during childhood were associated with an earlier age at menarche (from -1.3 to -4.6 months, P trend .0001) whereas greater family size, food deprivation during childhood, and greater birth weight resulted in a delayed menarche (from +1.5 months to +5.3 months, P trend .0001). Father's income index, urban birth place, and prematurity predicted a shorter time to menstrual cycle regularity (from -1.1 to -1.9 months, P trend .04), whereas birth cohort, larger body silhouette at menarche, and childhood exposure to passive smoking were associated with a longer time to menstrual cycle regularity (from +1.1 months to +8.6 months, P trend .006). Conclusions: Age at menarche and menstrual cycle regularity are significantly influenced by several individual, environmental and lifestyle factors.
机译：目的：初潮早期与几种主要的慢性病风险较高有关。尽管初潮年龄主要由遗传决定，但也与环境和生活方式因素有关。方法：使用线性回归模型，我们自1990年以来在法国E3N前瞻性队列研究中，同时探讨了数个产前和产后因素，这些因素是初潮年龄和月经周期规律的潜在决定因素。结果：征聘年龄越小，父亲的收入指数越高，城市出生地，出生时间越长以及童年时期的身材轮廓更大，则与初潮初潮的年龄相关（从-1.3到-4.6个月，P趋势<.0001）。更大的家庭规模，儿童时期的食物匮乏以及出生体重增加导致初潮延迟（从+1.5个月延长至+5.3个月，P趋势<.0001）。父亲的收入指数，城市出生地和早产预测到月经周期规律的时间较短（从-1.1到-1.9个月，P趋势<.04），而出生队列，初潮时的体形较大以及儿童暴露于被动吸烟的时间与月经周期规律的时间较长有关（从+1.1个月到+8.6个月，P趋势<.006）。结论：初潮年龄和月经周期规律受几个个人，环境和生活方式因素的显着影响。

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