• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cyclodextrin news >Effect of inorganic salts on the inclusion complex formation and solubilizing potency of cyclodextrins
【24h】

Effect of inorganic salts on the inclusion complex formation and solubilizing potency of cyclodextrins

机译：无机盐对环糊精的融合络合物形成和溶解效力的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The competition of hydrophobic molecules for the cyclodextrin (CD) cavity is well known and reported in the literature. However, it is not so trivial, how inorganic salts, small cations and anions may affect the inclusion complex formation, and thereby the functional properties of CDs. This topic is recently of particular interest for formulators since there are several granted patents and published patent applications on commercially available CD derivatives with certain intrinsic ion contents (in particular chloride and phosphate), such as US patents US7635773, US8410077, US9200088, US9493582 as well as US patent applications US2015284479 and US2015045311. All these documents highlight that the absence of these ions is specifically favored. On the other hand, the patent disclosing the SBE-BCD-based amiodarone formulation (US6869939) states that the advantage of using SBE-BCD is that a wider range of buffers was found compatible compared to other known (surfactant-containing) amiodarone-containing liquid formulations. Suitable buffering agents were enumerated such as phosphate and borate. In Example 10 of patent US6869939, a suitable formulation containing amiodarone HCl (50 mg/mL) in a solution containing 114 mM monobasic sodium phosphate and 30% w/v SBE-BCD is illustrating the advantageous use of phosphate ions in a SBE-BCD based formulation.
机译：疏水分子对环糊精（CD）腔的竞争在文献中是众所周知的。然而，这并不是那么小，无机盐，小阳离子和阴离子如何影响包含复合物的形成，从而如何影响CD的功能特性。最近，该主题特别感兴趣的配方剂，因为有几项授予专利和已发布的专利申请，这些专利申请具有某些内部离子含量（尤其是氯化物和磷酸盐），例如US专利US7635773，US7635773，US8410077，US9200088，US9493588，US94935582作为美国专利申请US2015284479和US2015045311。所有这些文件凸显了这些离子的缺失是特别有利于这些离子的。另一方面，专利披露基于SBE-BCD的胺碘酮配方（US6869939）指出，使用SBE-BCD的优点是，与其他已知的（表面活性剂）相比，发现了更宽的缓冲液兼容范围液体配方。列举了合适的缓冲剂，例如磷酸盐和硼酸盐。在示例10 US6869939的示例10中，在含有114 mM单体磷酸钠和30％W/V SBE-BCD的溶液中包含胺碘酮HCl（50 mg/ml）的合适配方，这说明了SBE-BCD磷酸盐离子中的优势基于公式。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号