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首页> 外文期刊>Cyclodextrin news >NPCM MODEL FOR PREDICTING THE EFFECT OF CD ON ORAL ABSORPTION OF LOW SOLUBILITY DRUGS
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NPCM MODEL FOR PREDICTING THE EFFECT OF CD ON ORAL ABSORPTION OF LOW SOLUBILITY DRUGS

机译：NPCM模型用于预测CD对低溶解性药物的口服吸收的影响

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In order to optimize the use of CD in a formulation to enhance oral absorption of a poorly soluble drug, it is important to understand which physical and chemical properties of drug and CD result in effective absorption enhancement. In addition, the properties of the biological environment where the drug is delivered should be taken into account. In order to address these needs, a model was developed predicting the influence of CD delivered as a physical mixture (as opposed to a pre-formed complex) on oral absorption and bioavailability of a compound delivered in its neutral form. A neutral compound physical mixture (NCPM) model was developed describing delivery of a drug to the GI tract in the presence of CD in both immediate release (IR) and controlled release (CR) formulations. The NCPM model is based on fundamentals of mass transport considering the physical and chemical properties of drug and CD. The main processes considered in the NCPM model are dissolution, complexation of drug with CD and absorption.
机译：为了优化在制剂中使用CD以增强溶解度不佳的药物的口服吸收，重要的是要了解药物和CD的物理和化学性质以及有效的吸收增强。此外，应考虑递送药物的生物环境的特性。为了满足这些需求，开发了一个模型，以预测CD作为物理混合物（与预成型复合物相反）对以其中性形式递送的化合物的口服吸收和生物利用度的影响。开发了一种中性化合物物理混合物（NCPM）模型，描述了在立即释放（IR）和受控释放（CR）制剂中CD存在下将药物递送到GI道的。 NCPM模型基于考虑药物和CD的物理和化学性质的质量转运基础。 NCPM模型中考虑的主要过程是溶解，药物与CD的络合和吸收。

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