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首页> 外文期刊>Clinical & translational oncology : >The detection and clinical significance of peripheral regulatory CD4(+)CD25(hi)CD127(low) T cells in patients with non-small cell lung cancer
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The detection and clinical significance of peripheral regulatory CD4(+)CD25(hi)CD127(low) T cells in patients with non-small cell lung cancer

机译：非小细胞肺癌患者外周调节CD4（+）CD25（HI）CD127（LOW）CD127（LOW）T细胞的检测及临床意义

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摘要

Objective In this study, we aimed to discuss the clinical significance of CD4(+)CD25(hi)CD127(low) regulatory T cells (Tregs) in the peripheral blood of patients with non-small cell lung cancer (NSCLC). Methods Sixty patients with NSCLC and 35 healthy controls were studied. Peripheral blood CD4(+)CD25(hi)CD127(low)Tregs, CD4(+)CD25(hi)T cells, and CD4(+)T cells were measured with flow cytometric analysis, and results were compared between the groups. Results Compared with healthy people, CD4(+)CD25(hi)CD127(low) Tregs and CD4(+)CD25(hi) T cells significantly increased in patients with NSCLC, while CD4(+) T cell proportions decreased. Conclusions CD4(+)CD25 (hi) CD127(low) Treg detection in the peripheral blood of NSCLC patients is highly significant, in that it provides additional knowledge to guide the selection of individualized treatment plans for patients with NSCLC.
机译：目的在这项研究中，我们旨在讨论非小细胞肺癌患者外周血（NSCLC）外周血CD4（+）CD25（HI）CD127（HI）CD127（Tregs）的临床意义。 方法研究了60例NSCLC和35例健康对照。 外周血CD4（+）CD25（HI）CD127（LOW）Tregs，CD4（+）CD25（HI）T细胞和CD4（+）T细胞与流式细胞术分析测量，并在组之间比较结果。 结果与健康人相比，CD4（+）CD25（HI）CD127（低）Tregs和CD4（+）CD25（HI）T细胞在NSCLC患者中显着增加，而CD4（+）T细胞比例降低。 结论CD4（+）CD25（HI）CD127（LOW）TREG检测在NSCLC患者外周血中是非常重要的，因为它提供了额外的知识，以指导NSCLC患者的个性化治疗计划的选择。

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    Qiu J.; Che G.; Liu F.; Sha X.; Ju S.; Ma H.; Feng L.;

  • 作者单位

    Nanjing Med Univ Suzhou Sci &

    Technol Town Hosp Affiliated Suzhou Hosp West Dist Dept Oncol;

    Sun Yat Sen Univ Affiliated Hosp 1 Dept Oncol Zhuhai 519000 Guangdong Peoples R China;

    Nanjing Med Univ Suzhou Sci &

    Technol Town Hosp Affiliated Suzhou Hosp Dept Cardiothorac Surg;

    Hongze Huaian Dist Peoples Hosp Dept Oncol Huaian 223100 Jiangsu Peoples R China;

    Nanjing Med Univ Affiliated Suzhou Hosp Dept Gastroenterol Suzhou 215006 Jiangsu Peoples R;

    Sun Yat Sen Univ Affiliated Hosp 1 Dept Oncol Zhuhai 519000 Guangdong Peoples R China;

    Nanjing Med Univ Suzhou Sci &

    Technol Town Hosp Affiliated Suzhou Hosp West Dist Dept Oncol;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Non-small cell lung cancer; CD4(+)CD25(hi)CD127(low)Treg; CD4(+)CD25(hi)T cells; CD4(+)T cells;

    机译：非小细胞肺癌;CD4（+）CD25（HI）CD127（低）Treg;CD4（+）CD25（HI）T细胞;CD4（+）T细胞;

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