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首页> 外文期刊>Annals of epidemiology >Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease.
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Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease.

机译：在患有心血管疾病的高危绝经后妇女中，性激素结合球蛋白和血清睾丸激素与C反应蛋白水平呈负相关。

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摘要

PURPOSE: C-reactive protein (CRP), androgens, and menopausal loss of endogenous estrogens are associated with cardiovascular disease (CVD). We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women. METHODS: CRP, SHBG, estradiol, and total testosterone were measured using baseline bloods of 221 hormone therapy (HT)-nonusers and 162 HT-users from a cross-sectional analysis in a nested case-control sample of the Women's Health Study. Hormones and CRP were ln-transformed and relationships were assessed with Spearman correlations and linear regression. RESULTS: ln-SHBG (beta=-0.40; p<0.01) and ln-testosterone (beta=-0.24; p=0.04) were the only independent hormonal predictors of ln-CRP among HT-nonusers after adjusting for age, hypertension, smoking, body mass index, diabetes, exercise, HDL cholesterol, alcohol intake, and CVD occurrence during follow-up. Upon stratification, the association between ln-SHBG and ln-CRP persisted among HT nonusers who subsequently developed CVD (beta=-0.55; p=0.01), but not among women who remained CVD-free (p=0.28). The inverse relationship between ln-SHBG and ln-CRP was strongest among the leanest women. None of the sex-hormones predicted ln-CRP among HT-users. CONCLUSIONS: SHBG and total testosterone were inversely associated with CRP among HT nonusers in this study. The relationship between SHBG and CRP was more strongly inverse among leaner women.
机译：目的：C反应蛋白（CRP），雄激素和内源性雌激素的更年期丢失与心血管疾病（CVD）有关。我们假设，绝经后妇女的高雄激素，低雌二醇和低性激素结合球蛋白（SHBG）与高CRP相关。方法：通过对妇女健康研究的嵌套病例对照样本进行横断面分析，使用221名非激素治疗（HT）使用者和162名HT使用者的基线血液来测量CRP，SHBG，雌二醇和总睾丸激素。对激素和CRP进行ln转换，并通过Spearman相关性和线性回归评估关系。结果：在调整年龄，高血压，随访期间吸烟，体重指数，糖尿病，运动，高密度脂蛋白胆固醇，酒精摄入和心血管疾病的发生。分层后，ln-SHBG和ln-CRP之间的关联在随后发展为CVD的HT非使用者中持续存在（β= -0.55; p = 0.01），而在没有CVD的女性中则没有（p = 0.28）。在最瘦的女性中，ln-SHBG与ln-CRP的反比关系最强。没有一种性激素能预测HT使用者中的ln-CRP。结论：HTB非使用者中SHBG和总睾丸激素与CRP呈负相关。在较瘦的女性中，SHBG和CRP之间的关系更为强烈。

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