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首页> 外文期刊>Annals of epidemiology >Evidence of the partial effects of inactivated Japanese encephalitis vaccination: analysis of previous outbreaks in Japan from 1953 to 1960.
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Evidence of the partial effects of inactivated Japanese encephalitis vaccination: analysis of previous outbreaks in Japan from 1953 to 1960.

机译：灭活日本脑炎疫苗接种的部分影响的证据：对1953年至1960年日本先前暴发的分析。

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摘要

PURPOSE: To evaluate the partial effects of vaccination against equine Japanese encephalitis (JE) and characterize other prognostic factors based on previous outbreak records in Japan from 1953 to 1960. METHODS: Individual case records, which included demographic information, vaccination history, and clinical information (dates of onset, recovery and death, and symptoms), were investigated. The relations between two outcomes, JE death and symptomatic period, and other variables were examined. RESULTS: Of a total reported 803 cases during the observation period, 453 (56.5%) were diagnosed with either serological, histopathological, or epizootiological methods. Vaccination (adjusted odds ratio=0.77, 95% confidence interval: 0.61, 0.97) and an older age (adjusted odds ratio=0.83, 95% confidence interval: 0.71, 0.96) significantly reduced the risk of JE death. The symptomatic period was also significantly shortened with vaccination (p<0.001). CONCLUSIONS: The risk of JE death was lowered and the symptomatic period of survivors shortened with inactivated JE vaccination. These findings demonstrate the partial effects of vaccination in reducing the burden of this disease.
机译：目的：根据1953年至1960年日本以前的疫情记录，评估疫苗接种对马日本脑炎（JE）的部分影响并鉴定其他预后因素。方法：个别病例记录，包括人口统计学信息，疫苗接种史和临床信息（发病日期，恢复，死亡日期和症状）进行了调查。研究了脑卒中死亡和症状期与两个变量之间的关系。结果：在观察期内报告的803例病例中，有453例（56.5％）被诊断为血清学，组织病理学或流行病学方法。接种疫苗（调整后的优势比= 0.77，95％置信区间：0.61、0.97）和年龄较大的人群（调整后的优势比= 0.83，95％置信区间：0.71、0.96）显着降低了JE死亡的风险。接种疫苗后症状期也明显缩短（p <0.001）。结论：灭活乙脑疫苗降低了乙脑死亡的风险，并缩短了幸存者的症状期。这些发现证明了疫苗接种在减轻该疾病负担方面的部分作用。

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