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首页> 外文期刊>Annals of epidemiology >Parity and cardiovascular disease risk among older women: how do pregnancy complications mediate the association?
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Parity and cardiovascular disease risk among older women: how do pregnancy complications mediate the association?

机译：老年妇女的均等和心血管疾病风险：妊娠并发症如何介导这种关联？

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PURPOSE: To determine whether parity is associated with increased risk of cardiovascular disease (CVD) after accounting for perinatal complications. METHODS: CVD prevalence, number of births, and a history of preeclampsia, term low birth weight, preterm or stillbirth were evaluated among 540 women (mean age, 80 years; 47% black) enrolled in the Pittsburgh, PA site of the Health, Aging and Body Composition Study. Biomarkers were measured and CVD status was determined by self-report and hospital records. RESULTS: Nulliparous women (n = 89) had lower CVD prevalence compared with parous women (18.0% vs. 30.2%). Parous women without perinatal complications of interest (n = 321) had higher statin use compared with nulliparas, a trend accompanied by lower high-density lipoprotein (HDL) and higher triglycerides among women with perinatal complications (n = 130). After adjustment, parous women with no complicated births had a 1.95-fold (95% confidence interval [CI], 1.03-3.7) higher CVD prevalence compared to nulliparas. Among women with one or more pregnancy complications, CVD prevalence was 2.67 times (CI, 1.34-5.33) higher. Women with five or more births had the highest CVD prevalence (odds ratio [OR], 2.60; CI, 1.17-5.76) that was attenuated to 2.27 (1.00-5.15) after adjustment for complications of interest. CONCLUSIONS: History of pregnancy complications and higher statin use accounted for some but not all of the excess CVD prevalence among older parous women.
机译：目的：确定产后并发症后，平价是否与心血管疾病（CVD）风险增加相关。方法：对宾夕法尼亚州匹兹堡市卫生局的540名女性（平均年龄，80岁; 47％的黑人）中的CVD患病率，分娩次数以及先兆子痫病史，足月低出生体重，早产或死产进行了评估，衰老和身体成分研究。测量生物标志物，并通过自我报告和医院记录确定CVD状态。结果：与产妇相比，无产妇（n = 89）的CVD患病率较低（18.0％比30.2％）。与无意产妇相比，无围产期并发症的产后妇女（n = 321）与他尼帕拉组相比使用他汀类药物的比例更高，这种趋势伴随着围产期并发症妇女（n = 130）中高密度脂蛋白（HDL）和甘油三酸酯含量降低。调整后，与无产妇相比，无复杂分娩的经产妇女的CVD患病率高1.95倍（95％可信区间[CI]，1.03-3.7）。在具有一种或多种妊娠并发症的女性中，CVD患病率高2.67倍（CI，1.34-5.33）。五个或五个以上分娩的妇女的CVD患病率最高（优势比[OR]为2.60; CI为1.17-5.76），在对相关并发症进行调整后，该比率降低至2.27（1.00-5.15）。结论：妊娠并发症的历史和他汀类药物的使用占老年parous妇女CVD患病率的一部分，但不是全部。

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