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首页> 外文期刊>Annals of epidemiology >Vitamin D and breast cancer.
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Vitamin D and breast cancer.

机译：维生素D和乳腺癌。

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Though the relationship between vitamin D and breast cancer remains unclear, a growing body of evidence suggests that vitamin D may modestly reduce risk. A large number of in vitro studies indicate that vitamin D can inhibit cell proliferation and promote apoptosis and cell differentiation in breast tumor tissue. Results from analytic studies of sunlight exposure and dietary intake have been inconsistent but together generally support a modestly protective role of vitamin D, at least in some population subgroups. Studies using blood vitamin D metabolites to assess vitamin D status may be less prone to misclassification than those of diet and sunlight exposure. Overall, the two prospective and four case-control studies of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D tend to support a protective effect in older women. The relationship between common vitamin D receptor polymorphisms and risk remains unclear. Many questions about this relationship clearly remain, including the utility of assessing vitamin D through diet and sunlight exposure, the relationship between plasma metabolites, and the potential modifying effects of age, menopausal status and tumor characteristics. Given that vitamin D status is modifiable, additional prospective studies are necessary to determine if vitamin D may have important potential for breast cancer prevention.
机译：尽管维生素D与乳腺癌之间的关系尚不清楚，但越来越多的证据表明，维生素D可能会适度降低风险。大量的体外研究表明，维生素D可以抑制乳腺肿瘤组织中的细胞增殖并促进细胞凋亡和细胞分化。对日光照射和饮食摄入的分析研究结果不一致，但至少在某些人群中，两者共同支持适度的维生素D保护作用。与饮食和阳光照射相比，使用血液中维生素D代谢物评估维生素D状况的研究更容易出现错误分类。总体而言，两项关于25-羟基维生素D和1,25-二羟基维生素D的前瞻性和四个病例对照研究倾向于支持老年妇女的保护作用。常见的维生素D受体多态性与风险之间的关系仍不清楚。关于这种关系的许多问题显然仍然存在，包括通过饮食和阳光照射评估维生素D的效用，血浆代谢产物之间的关系以及年龄，更年期状态和肿瘤特征的潜在修饰作用。鉴于维生素D的状态是可以修改的，因此有必要进行其他前瞻性研究，以确定维生素D是否可能具有预防乳腺癌的重要潜力。

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