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首页> 外文期刊>Annals of epidemiology >Serum lycopene and the risk of cancer: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study.
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Serum lycopene and the risk of cancer: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study.

机译：血清番茄红素与癌症风险：Kuopio缺血性心脏病风险因素（KIHD）研究。

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PURPOSE: Lycopene is thought to decrease the risk of cancers, although previous epidemiologic studies have produced inconsistent results. The aim of the present study was to evaluate the protective effect of lycopene against the risk of cancer. METHODS: The study population consisted of 997 middle-aged Finnish men in the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) cohort. During the mean follow-up time of 12.6 years, a total of 141 cancer cases appeared, of which 55 were prostate cancers. The association between the serum concentrations of lycopene and the risk of cancer was studied using the Cox proportional hazard models. RESULTS: An inverse association was observed between serum lycopene and overall cancer incidence. The adjusted risk ratio (RR) in the highest tertile of serum lycopene was 0.55 (95% confidence interval [CI], 0.34-0.89; p=0.015) compared with the lowest serum lycopene group. No association was observed between the lycopene concentrations and a prostate cancer risk. RR for other cancers was 0.43 (95% CI, 0.23-0.79; p=0.007). CONCLUSIONS: These findings suggest that in middle-aged men, the higher circulating concentrations of lycopene may contribute to the lower risk of cancer, with the exception of prostate cancer.
机译：目的：尽管以前的流行病学研究得出不一致的结果，但番茄红素被认为可以降低患癌症的风险。本研究的目的是评估番茄红素对癌症风险的保护作用。方法：研究人群由KUOPIO缺血性心脏病危险因素（KIHD）队列中的997名芬兰中年男性组成。在平均12.6年的随访时间中，总共出现141例癌症病例，其中55例为前列腺癌。使用Cox比例风险模型研究了番茄红素的血清浓度与癌症风险之间的关系。结果：血清番茄红素与总体癌症发生率呈负相关。与最低血清番茄红素组相比，最高血清番茄红素三分位数中的校正风险比（RR）为0.55（95％置信区间[CI]，0.34-0.89; p = 0.015）。在番茄红素浓度和前列腺癌风险之间未发现关联。其他癌症的RR为0.43（95％CI，0.23-0.79; p = 0.007）。结论：这些发现表明，在中年男性中，番茄红素的高循环浓度可能有助于降低患前列腺癌的风险。

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