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首页> 外文期刊>Annals of epidemiology >Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults
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Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults

机译：社区居民老年人的代谢综合征和16年认知下降

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Purpose: To determine whether metabolic syndrome is associated with accelerated cognitive decline in community-dwelling older adults. Methods: A longitudinal study of 993 adults (mean 66.8 ± 8.7 years) from the Rancho Bernardo Study. Metabolic syndrome components, defined by 2001 NCEP-ATP III criteria, were measured in 1984-1987. Cognitive function was first assessed in 1988-1992. Cognitive assessments were repeated approximately every 4 years, for a maximum 16-year follow-up. Mixed-effects models examined longitudinal rate of cognitive decline by metabolic syndrome status, controlling for factors plausibly associated with cognitive function (diabetes, inflammation). Results: Metabolic syndrome was more common in men than women (14% vs. 9%, p = .01). In women, metabolic syndrome was associated with greater executive function and long-term memory decline. These associations did not differ by inflammatory biomarker levels. Diabetes did not alter the association of metabolic syndrome with long-term recall but modified the association with executive function: metabolic syndrome was associated with accelerated executive function decline in diabetic women only. Metabolic syndrome was not related to rate of decline on any cognitive measure in men. Conclusions: Metabolic syndrome was a risk factor for accelerated cognitive decline, but only in women. Prevention of metabolic syndrome may aid in maintenance of cognitive function with age.
机译：目的：确定代谢综合征是否与社区居住的老年人加速的认知能力下降有关。方法：一项来自兰乔·伯纳多研究的993名成年人（平均66.8±8.7岁）的纵向研究。由2001 NCEP-ATP III标准定义的代谢综合征成分在1984-1987年进行了测量。认知功能于1988-1992年首次评估。大约每4年重复一次认知评估，最多随访16年。混合效应模型通过代谢综合征状态检查了认知能力下降的纵向速率，控制了可能与认知功能相关的因素（糖尿病，炎症）。结果：代谢综合征在男性中比女性更普遍（14％比9％，p = 0.01）。在女性中，代谢综合征与更高的执行功能和长期记忆力下降有关。这些关联在炎性生物标志物水平上没有差异。糖尿病并未改变代谢综合征与长期召回的关系，但改变了与执行功能的关系：仅在糖尿病女性中，代谢综合征与加速的执行功能下降相关。代谢综合征与男性任何认知指标的下降率均无关。结论：代谢综合征是加速认知能力下降的危险因素，但仅在女性中。预防代谢综合症可能有助于随着年龄的增长而维持认知功能。

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