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Association between number of children and mortality of mothers: Results of a 37-year follow-up study

机译：儿童数量与母亲死亡率之间的关联：一项为期37年的随访研究的结果

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Purpose: To examine the association between parity and long-term, all-cause mortality and mortality owing to specific causes in women. Methods: This prospective population-based study included 40,454 mothers who gave birth in Western Jerusalem, Israel, to 125,842 children and were followed for an average of 37 years after the birth of their first child. Cox proportional hazards models were used to evaluate long-term total and specific-cause mortality of women by their parity. Results: We found a U-shaped relationship between the number of offspring and risk of all-cause mortality in mothers. After adjustment for sociodemographic characteristics and maternal health and obstetric conditions, higher mortality rates were observed for mothers of 1 child (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.04-1.4), mothers of 5 to 9 children (HR, 1.21; 95% CI, 1.09-1.33), and mothers of 10 or more children (HR, 1.49; 95% CI, 1.12-1.99) compared with mothers of 2 to 4 children. Mortality risk from specific causes including coronary disease, circulatory disease, and cancer were increased for multiparous women. Conclusions: In this long-term follow-up study, there was an association between number of children and mortality risk for mothers. These findings suggest that maternal pregnancies and postnatal characteristics as reflected by number of children may have consequences for long-term maternal health. ? 2013 Elsevier Inc.
机译：目的：研究均等与长期全因死亡率和妇女特定原因造成的死亡率之间的关系。方法：这项基于人群的前瞻性研究包括40,454名在以色列西部耶路撒冷分娩的母亲，共有125,842名儿童，并在他们的第一个孩子出生后平均接受了37年的随访。使用Cox比例风险模型通过同等评估妇女的长期总和特定原因死亡率。结果：我们发现母亲的后代数量与全因死亡风险之间呈U型关系。调整了社会人口统计学特征以及孕产妇健康和产科状况后，发现有1个孩子的母亲死亡率更高（危险比[HR]为1.18; 95％置信区间[CI]为1.04-1.4），有5到9个孩子的母亲（HR，1.21; 95％CI，1.09-1.33），以及10个或更多孩子的母亲（HR，1.49; 95％CI，1.12-1.99），而2至4个孩子的母亲。多胎女性因特定原因而导致的死亡率风险增加，包括冠心病，循环系统疾病和癌症。结论：在这项长期随访研究中，儿童数量与母亲的死亡风险之间存在关联。这些发现表明，由儿童数量所反映的孕产和产后特征可能对长期孕产妇健康产生影响。 ？ 2013爱思唯尔公司

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