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首页> 外文期刊>Annals of epidemiology >Utility of proxy versus index respondent information in a population-based case-control study of rapidly fatal cancers.
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Utility of proxy versus index respondent information in a population-based case-control study of rapidly fatal cancers.

机译：代理与索引响应者信息在基于人群的快速致命癌症病例对照研究中的效用。

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摘要

PURPOSE: This work provides an empirical assessment of the usefulness of obtaining exposure data from proxy respondents. METHODS: Two independent case groups were formed in data from a population-based case-control study. One case set was derived from proxy respondents. The second case series was derived from respondents who self-reported. The second case group was matched to the proxy case group for age, cancer site, and sex. These data were compared with a control group for completeness of information and identifying heterogeneity of risk estimates for a variety of variables. Index cases and controls were matched to the 829 available proxy respondents for sex, age (5-year groups), and cancer site. RESULTS: Proxy respondents provided levels of complete information similar to index cases and controls for height and weight; occupational physical activity; consumption of coffee, alcohol, and cigarettes; and family history of cancer. Proxies had more missing responses for variables concerning recreationalphysical activity, clinical depression, age at first menstruation, use of oral contraceptives, and occupational exposure to pesticides. Polytomous logistic regression models found only a few examples of meaningful heterogeneity among all variables, limited to models for coffee consumption and cigarette smoking. CONCLUSIONS: Our data suggest that proxy respondents, especially parents and spouses, provide adequately complete information for many, but not all, exposures common in epidemiologic studies.
机译：目的：这项工作对从代理受访者那里获得暴露数据的有效性进行了实证评估。方法：在基于人群的病例对照研究数据中形成了两个独立的病例组。一个案例集来自代理受访者。第二个案例系列来自自我报告的受访者。第二个病例组与代理病例组在年龄，癌症部位和性别方面相匹配。将这些数据与对照组进行比较，以确保信息的完整性并确定各种变量的风险估计值的异质性。将索引病例和对照与829个可用的性别，年龄（5岁组）和癌症部位的代理调查对象相匹配。结果：代理调查对象提供了与索引案例和身高和体重控制类似的完整信息水平;职业体育活动;消费咖啡，酒精和香烟;和癌症的家族史。对于娱乐体力活动，临床抑郁，月经初潮，口服避孕药和职业性接触农药等变量，代理人缺少更多响应。多变量逻辑回归模型仅在所有变量中发现了有意义的异质性的几个例子，仅限于咖啡消费和吸烟的模型。结论：我们的数据表明，代理人（尤其是父母和配偶）为流行病学研究中许多但不是全部的暴露提供了足够完整的信息。

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